Lymph node metastasis from non-melanoma skin cancer Review
| Authors: | Woods, R. S. R.; Woods, J. F. C.; Fitzgerald, C. W. R.; Alameer, E.; Lopez, J.; Singh, B.; Shah, J. P. |
| Review Title: | Lymph node metastasis from non-melanoma skin cancer |
| Abstract: | The management of non-melanoma skin cancers metastatic to the neck is challenging due to variability in biological behavior and patterns of regional lymphatic spread. Metastatic non-melanoma skin cancers to the parotid and neck often behave aggressively, with a high incidence of local recurrence after treatment and reduced five-year survival outcomes. Patterns of lymphatic spread are different from those seen in mucosal squamous cell carcinoma, with higher prevalence of disease in the parotid and superficial lymphatics. These factors require that treatment is individualized to achieve optimal outcomes. Traditionally, the management of non-melanoma skin cancers metastatic to lymph nodes has involved surgical excision followed by adjuvant radiation therapy. However, novel systemic therapies are showing promising results and their role in the management of these cancers is evolving. © The Author(s) 2022. |
| Keywords: | lymph nodes; lymphatic metastasis; skin neoplasms; neck; non-melanoma cutaneous malignancy |
| Journal Title: | Journal of Cancer Metastasis and Treatment |
| Volume: | 8 |
| ISSN: | 2394-4722 |
| Publisher: | OAE Publishing Inc. |
| Date Published: | 2022-01-01 |
| Start Page: | 4889 |
| Language: | English |
| DOI: | 10.20517/2394-4722.2022.28 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Published in special issue named "Topic: Lymph Node Metastases in the Neck" -- Export Date: 1 August 2022 -- Source: Scopus |
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