Fecal microbiota transplantation is safe for Clostridiodies difficile infection in patients with solid tumors undergoing chemotherapy Journal Article

   

Authors:	Mendelsohn, R. B.; Kaltsas, A.; King, S.; Hwang, C.; Kassam, Z.; Abend, A. M.; Kramer, E.; Kamboj, M.
Article Title:	Fecal microbiota transplantation is safe for Clostridiodies difficile infection in patients with solid tumors undergoing chemotherapy
Abstract:	Background Recurrent Clostridiodies difficile infection (CDI) contributes to morbidity and mortality in cancer patients. Fecal microbiota transplantation (FMT) has been proven to be effective in treatment of recurrent CDI, but immunocompromised patients have been excluded from prospective studies due to safety concerns. The aim of this study was to investigate the safety of FMT for recurrent CDI in immunocompromised patients with solid tumor malignancy undergoing chemotherapy. Methods This was a single center, prospective observational study of patients at a tertiary care cancer center of 10 patients with recurrent CDI who were at least 18 years of age, with a solid tumor malignancy who had received chemotherapy within the previous 6 months. Patients received FMT either by upper endoscopy or colonoscopy and were followed for 6 months. Safety was a primary outcome measured by infections occurring within 2 weeks of FMT. Efficacy of FMT was also evaluated. Results Nineteen patients were evaluated. On applying exclusion criteria, 10 were included in the study. One patient requested to be off study within 2 weeks and was considered a treatment failure. Seven received FMT via upper endoscopy, three via colonoscopy. There were no infectious complications from FMT. Eight patients (80%) were cured after the first FMT. All eight patients went on to restart oncologic treatment with an average of 32.5 days after FMT. Conclusions FMT is safe and effective for recurrent CDI in solid tumor patients undergoing chemotherapy. Patients can resume oncologic treatment after FMT.
Keywords:	chemotherapy; infection; bacteremia; surveillance; cancer; fecal microbiota transplantation; recurrent clostridiodies difficile
Journal Title:	Digestive Diseases and Sciences
Volume:	67
Issue:	6
ISSN:	0163-2116
Publisher:	Springer
Date Published:	2022-06-01
Start Page:	2503
End Page:	2509
Language:	English
ACCESSION:	WOS:000658142000004
DOI:	10.1007/s10620-021-07024-z
PROVIDER:	wos
PUBMED:	34089134
PMCID:	PMC10007693
Notes:	Article -- Source: Wos

https://synapse.mskcc.org/synapse/works/has_related_data_chk/195773