Genotypic correlation between post discharge Clostridiodes difficle infection (CDI) and previous unit-based contacts Journal Article
| Authors: | Babady, N. E.; Aslam, A.; McMillen, T.; Syed, M.; Zehir, A.; Kamboj, M. |
| Article Title: | Genotypic correlation between post discharge Clostridiodes difficle infection (CDI) and previous unit-based contacts |
| Abstract: | Background: Cases of Clostridiodes difficile infection (CDI) diagnosed after hospital discharge account for a substantial proportion of new infections. It is unclear whether post-discharge infections originate from hospital-based transmission. Methods: This was a Retrospective cohort study at a tertiary-care cancer center (non-outbreak setting). For all laboratory-identified cases of CDI in 2015–2016, patients with post-discharge (PD) CDI within eight weeks of their hospital stay were included in the study. Isolates from PD-CDI cases and their CDI-positive unit-based contacts were first genotyped by multilocus sequence typing (MLST). Common strains were further examined by core genome sequencing (CGS) to evaluate transmission links. Results: Of 173 cases examined by MLST, 50% of PD cases matched previous unit contacts. Next, 34 isolates, including 16 PD cases and their 18-unit contacts were examined by CGS. None were ≤3 single-nucleotide variants apart. Seventy percent of PD cases had in-hospital antibiotic exposure before CDI onset in the community. Conclusion: Our study results suggest that symptomatic CDI cases are not a substantial source of transmission to PD cases. Frequent antibiotic exposure in post-discharge CDI cases is an important target for surveillance and stewardship efforts. © 2020 |
| Keywords: | clostridium difficile; genome sequencing; post-discharge infection |
| Journal Title: | Journal of Hospital Infection |
| Volume: | 109 |
| ISSN: | 0195-6701 |
| Publisher: | W.B. Saunders Co. |
| Date Published: | 2021-03-01 |
| Start Page: | 96 |
| End Page: | 100 |
| Language: | English |
| DOI: | 10.1016/j.jhin.2020.10.028 |
| PUBMED: | 33171187 |
| PROVIDER: | scopus |
| PMCID: | PMC8456756 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 March 2021 -- Source: Scopus |
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