PD-L1 expression and overall survival in Asian and western patients with gastric cancer Journal Article
| Authors: | Rha, S. Y.; Ku, G. Y.; Kim, H. S.; Chung, H. C.; Amlashi, F. G.; Maru, D. M.; Fein, C. A.; Tang, L. H.; Zhou, W.; Wu, T.; Peter, S. A.; Kelsen, D. P.; Ajani, J. A. |
| Article Title: | PD-L1 expression and overall survival in Asian and western patients with gastric cancer |
| Abstract: | Aim: Data are limited on PD-L1 expression and its association with overall survival (OS) in gastric cancer (GC) patients receiving routine care in different regions. Materials & methods: In a retrospective study, PD-L1 expression was assayed using the 22C3 pharmDx on GC tumor samples collected between 2003 and 2017 at South Korean and US cancer centers. PD-L1 positivity was defined as combined positive score (CPS) ≥1. The relationship between PD-L1 and OS was analyzed. Results: Of 574 GC tumor samples, 67.4% were CPS ≥1 (68.7% in Korean and 65.7% in US patients). PD-L1 expression was not associated with OS (adjusted hazard ratio: 0.94; 95% CI: 0.75-1.17). Conclusion: PD-L1 prevalence and its association with OS was similar between South Korean and US GC patients. © 2022 Future Medicine Ltd. |
| Keywords: | overall survival; gastric cancer; expression; pd-l1; prognosis |
| Journal Title: | Future Oncology |
| Volume: | 18 |
| Issue: | 21 |
| ISSN: | 1479-6694 |
| Publisher: | Future Medicine |
| Date Published: | 2022-07-01 |
| Start Page: | 2623 |
| End Page: | 2634 |
| Language: | English |
| DOI: | 10.2217/fon-2022-0103 |
| PUBMED: | 35616013 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 July 2022 -- Source: Scopus |
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