Prognostic significance of T-cell-inflamed gene expression profile and PD-L1 expression in patients with esophageal cancer Journal Article
| Authors: | Steiniche, T.; Rha, S. Y.; Chung, H. C.; Georgsen, J. B.; Ladekarl, M.; Nordsmark, M.; Jespersen, M. L.; Kim, H. S.; Kim, H.; Fein, C.; Tang, L. H.; Wu, T.; Marton, M. J.; Peter, S.; Kelsen, D. P.; Ku, G. |
| Article Title: | Prognostic significance of T-cell-inflamed gene expression profile and PD-L1 expression in patients with esophageal cancer |
| Abstract: | Purpose: The ability of the T-cell–inflamed gene expression profile (GEP) to predict clinical outcome in esophageal cancer (EC) is unknown. This retrospective observational study assessed the prognostic value of GEP and programmed death ligand 1 (PD-L1) expression in patients with EC treated in routine clinical practice. Methods: Tumor samples of 294 patients from three centers in Denmark, South Korea, and the United States, collected between 2005 and 2017, were included. T-cell–inflamed GEP score was defined as non-low or low using a cutoff of −1.54. A combined positive score (CPS) ≥10 was defined as PD-L1 expression positivity. Associations between overall survival (OS) and GEP status and PD-L1 expression were explored by Cox proportional hazards models adjusting for age, sex, histology, stage, and performance status. Results: Median age was 65 years; 63% of patients had adenocarcinoma (AC) and 37% had squamous cell carcinoma (SCC). Thirty-six percent of tumors were GEP non-low, with higher prevalence in AC (46%) than SCC (18%). Twenty-one percent were PD-L1–positive: 32% in South Korean samples versus 16% in non-Asian samples and 26% in SCC versus 18% in AC. GEP scores and PD-L1 CPS were weakly correlated (Spearman’s R = 0.363). OS was not significantly associated with GEP status (non-low vs low; adjusted hazard ratio, 0.91 [95% CI, 0.69–1.19]) or PD-L1 expression status. Conclusion: Neither GEP nor PD-L1 expression was a prognostic marker in Asian and non-Asian patients with EC. © 2021 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. |
| Keywords: | squamous cell carcinoma; adenocarcinoma; t-lymphocytes; retrospective study |
| Journal Title: | Cancer Medicine |
| Volume: | 10 |
| Issue: | 23 |
| ISSN: | 2045-7634 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2021-12-01 |
| Start Page: | 8365 |
| End Page: | 8376 |
| Language: | English |
| DOI: | 10.1002/cam4.4333 |
| PROVIDER: | scopus |
| PMCID: | PMC8633232 |
| PUBMED: | 34693652 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 3 January 2022 -- Source: Scopus |
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