Allogeneic tumor antigen-specific T cells for broadly applicable adoptive cell therapy of cancer Journal Article
| Authors: | Molvi, Z.; O’Reilly, R. J. |
| Article Title: | Allogeneic tumor antigen-specific T cells for broadly applicable adoptive cell therapy of cancer |
| Abstract: | T cells specific for major histocompatibility complex (MHC)-presented tumor antigens are capable of inducing durable remissions when adoptively transferred to patients with refractory cancers presenting such antigens. When such T cells are derived from healthy donors, they can be banked for off-the-shelf administration in appropriately tissue matched patients. Therefore, tumor antigen-specific, donor-derived T cells are expected to be a mainstay in the cancer immunotherapy armamentarium. In this chapter, we analyze clinical evidence that tumor antigen-specific donor-derived T cells can induce tumor regressions when administered to appropriately matched patients whose tumors are refractory to standard therapy. We also delineate the landscape of MHC-presented and unconventional tumor antigens recognized by T cells in healthy individuals that have been targeted for adoptive T cell therapy, as well as emerging antigens for which mounting evidence suggests their utility as targets for adoptive T cell therapy. We discuss the growing technological advancements that have facilitated sequence identification of such antigens and their cognate T cells, and applicability of such technologies in the pre-clinical and clinical settings. © 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG. |
| Keywords: | neoplasm; neoplasms; t lymphocyte; t-lymphocytes; hematopoietic stem cell transplantation; tumor antigen; antigens, neoplasm; tumor antigens; peptide vaccine; adoptive immunotherapy; immunotherapy, adoptive; t cell receptor; donor leukocyte infusions; humans; human; adoptive t cell therapy; graft versus leukemia; allogeneic t cell therapy; healthy donor t cells; human leukocyte antigens; off-the-shelf t cell therapy |
| Journal Title: | Cancer Treatment and Research |
| Volume: | 183 |
| ISSN: | 0927-3042 |
| Publisher: | Springer |
| Date Published: | 2022-05-13 |
| Start Page: | 131 |
| End Page: | 159 |
| Language: | English |
| DOI: | 10.1007/978-3-030-96376-7_4 |
| PUBMED: | 35551658 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Chapter 4 in "Cancer Immunotherapies: Solid Tumors and Hematologic Malignancies" (ISBN: 978-3-030-96375-0) -- Export Date: 1 June 2022 -- Source: Scopus |
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