Virus-specific T-cell banks for 'off the shelf' adoptive therapy of refractory infections Journal Article

   


Authors: O'Reilly, R. J.; Prockop, S.; Hasan, A. N.; Koehne, G.; Doubrovina, E.
Article Title: Virus-specific T-cell banks for 'off the shelf' adoptive therapy of refractory infections
Abstract: Adoptive immunotherapy with transplant donor-derived virus-specific T cells has emerged as a potentially curative approach for the treatment of drug-refractory EBV+lymphomas as well as CMV and adenovirus infections complicating allogeneic hematopoietic cell transplants. Adoptive transfer of HLA partially matched virus-specific T cells from healthy third party donors has also shown promise in the treatment of these conditions, with disease response rates of 50-76% and strikingly low incidences of toxicity or GVHD recorded in initial trials. In this review, we examine the reported experience with transplant donor and third party donor-derived virus-specific T cells, identifying characteristics of the viral pathogen, the T cells administered and the diseased host that contribute to treatment response or failure. We also describe the characteristics of virus-specific T-cell lines in our center's bank and the frequency with which in vitro culture promotes expansion of immunodominant T cells specific for epitopes that are presented by a limited array of prevalent HLA alleles, which facilitates their broad applicability for treatment. © 2016 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.
Journal Title: Bone Marrow Transplantation
Volume: 51
Issue: 9
ISSN: 0268-3369
Publisher: Nature Publishing Group  
Date Published: 2016-09-01
Start Page: 1163
End Page: 1172
Language: English
DOI: 10.1038/bmt.2016.17
PROVIDER: scopus
PUBMED: 27042851
PMCID: PMC5356365
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-84962071072&partnerID=40&md5=9472338a1bd4fc5249495e10b52ec888
Notes: Review -- Export Date: 3 October 2016 -- Source: Scopus
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MSK Authors
  1. Susan E Prockop
    262 Prockop
  2. Guenther Koehne
    194 Koehne
  3. Ekaterina Doubrovina
    101 Doubrovina
  4. Aisha Nasreen Hasan
    56 Hasan
  5. Richard O'Reilly
    747 O'Reilly
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