Therapeutic advantages provided by banked virus-specific T-cells of defined HLA-restriction Review

  


Authors: O’Reilly, R. J.; Prockop, S.; Hasan, A.; Doubrovina, E.
Review Title: Therapeutic advantages provided by banked virus-specific T-cells of defined HLA-restriction
Abstract: We have developed banks of EBV and CMV-specific T-cell lines generated from healthy seropositive third party donors and characterized them as to their HLA type, virus specificity, lack of alloreactivity, and HLA restriction. We here summarize results of studies employing these immediately accessible, broadly-applicable third party virus-specific T-cells for adoptive therapy of EBV lymphomas and CMV infections in allo-HCT recipients. We describe the characteristics contributing to their safety. We also discuss several distinctive advantages of banked third party virus-specific T-cells selected on the basis of their HLA restriction, particularly in the treatment of Rituximab-non-responsive EBV+ lymphomas and drug refractory CMV infections complicating HLA non-identical transplants. © 2019, The Author(s), under exclusive licence to Springer Nature Limited.
Journal Title: Bone Marrow Transplantation
Volume: 54
Issue: Suppl. 2
ISSN: 0268-3369
Publisher: Nature Publishing Group  
Date Published: 2019-08-01
Start Page: 759
End Page: 764
Language: English
DOI: 10.1038/s41409-019-0614-1
PROVIDER: scopus
PUBMED: 31431697
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85070828816&doi=10.1038%2fs41409-019-0614-1&partnerID=40&md5=47ed32758ae4b3e26e7749507865645a
Notes: Review -- Source: Scopus
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MSK Authors
  1. Susan E Prockop
    262 Prockop
  2. Ekaterina Doubrovina
    101 Doubrovina
  3. Aisha Nasreen Hasan
    56 Hasan
  4. Richard O'Reilly
    747 O'Reilly
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