Adoptive transfer of unselected or leukemia-reactive T-cells in the treatment of relapse following allogeneic hematopoietic cell transplantation Journal Article


Authors: O'Reilly, R. J.; Dao, T.; Koehne, G.; Scheinberg, D.; Doubrovina, E.
Article Title: Adoptive transfer of unselected or leukemia-reactive T-cells in the treatment of relapse following allogeneic hematopoietic cell transplantation
Abstract: Adoptive transfer of in vivo generated antigen-specific donor-derived T-cells is increasingly recognized as an effective approach for the treatment or prevention of EBV lymphomas and cytomegalovirus infections complicating allogeneic hematopoietic cell transplants. This review examines evidence from preclinical experiments and initial clinical trials to critically assess both the potential and current limitations of adoptive transfer of donor T-cells sensitized to selected minor alloantigens of the host or to peptide epitopes of proteins, differentially expressed by clonogenic leukemia cells, such as the Wilms tumor protein, WT-1, as a strategy to treat or prevent recurrence of leukemia in the post-transplant period. © 2010 Elsevier Ltd.
Keywords: protein expression; leukemia; transplantation, homologous; unclassified drug; oncoprotein; acute granulocytic leukemia; clinical trial; review; nonhuman; clinical trials as topic; protein function; t lymphocyte; t-lymphocytes; animals; mice; cell survival; cancer immunotherapy; granulocyte macrophage colony stimulating factor; recurrence; cyclophosphamide; hematopoietic stem cell transplantation; antineoplastic activity; cytotoxicity; chronic myeloid leukemia; t lymphocyte receptor; lymphocyte activation; myelodysplastic syndrome; whole body radiation; cellular immunity; amino acid sequence; molecular sequence data; immunotherapy; leukemia cell; graft versus host reaction; donor lymphocyte infusion; allogeneic hematopoietic stem cell transplantation; adoptive transfer; acute lymphocytic leukemia; peptide vaccine; t cell depletion; leukemia relapse; epitopes, t-lymphocyte; alloantigen; adoptive immunotherapy; interleukin 15; t-cell; wt1 proteins; allogeneic; leukemia-targeted; emulsifying agent; montanide; protein wt 1; wt 1 peptide vaccine
Journal Title: Seminars in Immunology
Volume: 22
Issue: 3
ISSN: 1044-5323
Publisher: Academic Press Inc., Elsevier Science  
Date Published: 2010-06-01
Start Page: 162
End Page: 172
Language: English
DOI: 10.1016/j.smim.2010.02.003
PUBMED: 20537908
PROVIDER: scopus
PMCID: PMC4183056
DOI/URL:
Notes: --- - "Export Date: 20 April 2011" - "CODEN: SEIME" - "Source: Scopus"
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MSK Authors
  1. Guenther Koehne
    194 Koehne
  2. Tao Dao
    71 Dao
  3. Richard O'Reilly
    697 O'Reilly