Targeting mutations in cancer Journal Article


Authors: Waarts, M. R.; Stonestrom, A. J.; Park, Y. C.; Levine, R. L.
Article Title: Targeting mutations in cancer
Abstract: Targeted therapies have come to play an increasingly important role in cancer therapy over the past two decades. This success has been made possible in large part by technological advances in sequencing, which have greatly advanced our understanding of the mutational landscape of human cancer and the genetic drivers present in individual tumors. We are rapidly discovering a growing number of mutations that occur in targetable pathways, and thus tumor genetic testing has become an important component in the choice of appropriate therapies. Targeted therapy has dramatically transformed treatment outcomes and disease prognosis in some settings, whereas in other oncologic contexts, targeted approaches have yet to demonstrate considerable clinical efficacy. In this Review, we summarize the current knowledge of targetable mutations that occur in a range of cancers, including hematologic malignancies and solid tumors such as non-small cell lung cancer and breast cancer. We outline seminal examples of druggable mutations and targeting modalities and address the clinical and research challenges that must be overcome to maximize therapeutic benefit. Copyright: © 2022, Waarts et al.
Journal Title: Journal of Clinical Investigation
Volume: 132
Issue: 8
ISSN: 0021-9738
Publisher: American Society for Clinical Investigation  
Date Published: 2022-04-15
Start Page: e154943
Language: English
DOI: 10.1172/jci154943
PUBMED: 35426374
PROVIDER: scopus
PMCID: PMC9012285
DOI/URL:
Notes: Article -- Export Date: 2 May 2022 -- Source: Scopus
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MSK Authors
  1. Ross Levine
    634 Levine
  2. Young Park
    8 Park
  3. Michael R Waarts
    2 Waarts