Systemic therapy for gallbladder cancer Review


Authors: Javle, M.; Zhao, H.; Abou-Alfa, G. K.
Review Title: Systemic therapy for gallbladder cancer
Abstract: Gallbladder cancer is an aggressive cancer that continues to be an important health care issue in certain regions of the world such as Southeast Asia and Latin America. Most patients are diagnosed at an advanced, unresectable stage and systemic therapy is their only option. Gallbladder cancer patients have traditionally been included in clinical trials for biliary tract cancer. Thus, systemic chemotherapy options for this cancer are similar to those for cholangiocarcinoma, including gemcitabine and cisplatin in the first line and FOLFOX in the second-line setting. Ongoing phase III clinical trials may change the systemic therapy paradigm for this cancer. Molecular profiling has indicated important genetic differences between gallbladder cancer and cholangio-carcinoma, which affects choice of targeted therapy. Her2/neu amplification, PIK3CA mutations and DNA repair genetic aberrations are relatively frequent and represent actionable targets for this cancer. © Chinese Clinical Oncology. All rights reserved.
Keywords: targeted therapy; cancer of gallbladder; genes erbb2
Journal Title: Chinese Clinical Oncology
Volume: 8
Issue: 4
ISSN: 2304-3865
Publisher: AME Publishing Company  
Date Published: 2019-08-01
Start Page: 44
Language: English
DOI: 10.21037/cco.2019.08.14
PUBMED: 31484490
PROVIDER: scopus
DOI/URL:
Notes: Article -- Export Date: 1 October 2019 -- Source: Scopus
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  1. Ghassan Abou-Alfa
    421 Abou-Alfa