When genome maintenance goes badly awry Journal Article


Authors: Kass, E. M.; Moynahan, M. E.; Jasin, M.
Article Title: When genome maintenance goes badly awry
Abstract: Genetic abnormalities are present in all tumor types, although the frequency and type can vary. Chromosome abnormalities include highly aberrant structures, particularly chromothriptic chromosomes. The generation of massive sequencing data has illuminated the scope of the mutational burden in cancer genomes, identifying patterns of mutations (mutation signatures), which have the potential to shed light on the relatedness and etiologies of cancers and impact therapy response. Some mutation patterns are clearly attributable to disruptions in pathways that maintain genomic integrity. Here we review recent advances in our understanding of genetic changes occurring in cancers and the roles of genome maintenance pathways. © 2016 Elsevier Inc.
Keywords: homologous recombination; brca1; brca2; chromothripsis; cancer genomes; kataegis; mutation signature
Journal Title: Molecular Cell
Volume: 62
Issue: 5
ISSN: 1097-2765
Publisher: Cell Press  
Date Published: 2016-06-02
Start Page: 777
End Page: 787
Language: English
DOI: 10.1016/j.molcel.2016.05.021
PROVIDER: scopus
PUBMED: 27259208
PMCID: PMC4966655
DOI/URL:
Notes: Review -- Export Date: 1 July 2016 -- Source: Scopus
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MSK Authors
  1. Mary Ellen Moynahan
    105 Moynahan
  2. Maria Jasin
    240 Jasin
  3. Elizabeth M Kass
    13 Kass