Splicing-mediated antigen escape from immunotherapy for B-cell malignancies Editorial
| Authors: | Bourcier, J.; Abdel-Wahab, O. |
| Title: | Splicing-mediated antigen escape from immunotherapy for B-cell malignancies |
| Abstract: | In this issue of Blood Cancer Discovery, Zheng and colleagues identify that alternative RNA splicing of CD22 within B-cell acute lymphoblastic leukemia can result in antigen escape from CD22-targeted immunotherapies. Drug-resistant isoforms of CD22 exist within leukemic cells pretreatment and can influence response to the CD22-directed antibody-drug conjugate inotuzumab ozogamicin, the immunotoxin moxetumomab pasudotox, as well as anti-CD22 chimeric antigen receptor T cells. |
| Journal Title: | Blood Cancer Discovery |
| Volume: | 3 |
| Issue: | 2 |
| ISSN: | 2643-3230 |
| Publisher: | American Association for Cancer Research |
| Date Published: | 2022-03-01 |
| Start Page: | 87 |
| End Page: | 89 |
| Language: | English |
| ACCESSION: | WOS:000767279000001 |
| DOI: | 10.1158/2643-3230.Bcd-21-0200 |
| PROVIDER: | wos |
| PUBMED: | 35015686 |
| Notes: | Editorial Material -- Source: Wos |
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