Understanding language reorganization with neuroimaging: How language adapts to different focal lesions and insights into clinical applications Review

   

Authors:	Pasquini, L.; Di Napoli, A.; Rossi-Espagnet, M. C.; Visconti, E.; Napolitano, A.; Romano, A.; Bozzao, A.; Peck, K. K.; Holodny, A. I.
Review Title:	Understanding language reorganization with neuroimaging: How language adapts to different focal lesions and insights into clinical applications
Abstract:	When the language-dominant hemisphere is damaged by a focal lesion, the brain may reorganize the language network through functional and structural changes known as adaptive plasticity. Adaptive plasticity is documented for triggers including ischemic, tumoral, and epileptic focal lesions, with effects in clinical practice. Many questions remain regarding language plasticity. Different lesions may induce different patterns of reorganization depending on pathologic features, location in the brain, and timing of onset. Neuroimaging provides insights into language plasticity due to its non-invasiveness, ability to image the whole brain, and large-scale implementation. This review provides an overview of language plasticity on MRI with insights for patient care. First, we describe the structural and functional language network as depicted by neuroimaging. Second, we explore language reorganization triggered by stroke, brain tumors, and epileptic lesions and analyze applications in clinical diagnosis and treatment planning. By comparing different focal lesions, we investigate determinants of language plasticity including lesion location and timing of onset, longitudinal evolution of reorganization, and the relationship between structural and functional changes. Copyright © 2022 Pasquini, Di Napoli, Rossi-Espagnet, Visconti, Napolitano, Romano, Bozzao, Peck and Holodny.
Keywords:	stroke; tumor; fmri; language; epilepsy; plasticity; reorganization; dti—diffusion tensor imaging
Journal Title:	Frontiers in Human Neuroscience
Volume:	16
ISSN:	1662-5161
Publisher:	Frontiers Research Foundation
Date Published:	2022-02-18
Start Page:	747215
Language:	English
DOI:	10.3389/fnhum.2022.747215
PROVIDER:	scopus
PMCID:	PMC8895248
PUBMED:	35250510
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85125868158&doi=10.3389%2ffnhum.2022.747215&partnerID=40&md5=ac0a8a6187a1838e44175928d76786c7
Notes:	Review -- Export Date: 1 April 2022 -- Source: Scopus

https://synapse.mskcc.org/synapse/works/has_related_data_chk/193399