Language reorganization in patients with left-hemispheric gliomas is associated with increased cortical volume in language-related areas and in the default mode network Journal Article

   

Authors:	Pasquini, L.; Jenabi, M.; Peck, K. K.; Holodny, A. I.
Article Title:	Language reorganization in patients with left-hemispheric gliomas is associated with increased cortical volume in language-related areas and in the default mode network
Abstract:	Background: Language function may reorganize to overcome focal impairment; however, the relation between functional and structural changes in patients with brain tumors remains unclear. We investigated the cortical volume of atypical language dominant (AD) patients with left frontal-insular high-grade (HGG) and low-grade glioma (LGG). We hypothesized atypical language being associated with areas of increased cortical volume in the right hemisphere, including language areas homologues. Methods: Patient were recruited following the criteria: left frontal-insular glioma; functional MRI and 3DT1-weighted images; no artifacts. We calculated an hemispheric language laterality index (LI), defined as: AD if LI <.2; left-dominant (LD) if LI ≥.2. We measured cortical volume in three voxel-based morphometry (VBM) analyses: total AD vs. LD patients; AD vs. LD in HGG; AD vs. LD in LGG. We repeated the analysis in AD vs. LD healthy controls (HC). A minimum threshold of t > 2 and corrected p <.025 (Bonferroni) was employed. Results: We recruited 119 patients (44LGG, 75HGG). Hemispheric LI demonstrated 64/119AD and 55/119LD patients. The first VBM analysis demonstrated significantly increased cortical volume in AD patients in the right inferior frontal gyrus (IFG), right superior temporal gyrus (STG), right insula, right fusiform gyrus (FG), right precentral gyrus, right temporal–parietal junction, right posterior cingulate cortex (PCC), right hippocampus, right- and left cerebellum. AD patients with HGG showed the same areas of significantly increased cortical volume. AD patients with LGG displayed significantly increased cortical volume in right IFG, right STG, right insula, right FG, right anterior cingulate cortex, right PCC, right dorsal-lateral prefrontal cortex. HC showed no significant results. Conclusion: Right-sided (atypical) language activations in patients with left-hemispheric gliomas are associated with areas of increased cortical volume. Additionally, default mode network nodes showed greater cortical volume in AD patients regardless of the tumor grade, supporting the idea of these cortices participating in the development of language plasticity. © 2022 Elsevier Ltd
Keywords:	adult; controlled study; major clinical study; comparative study; glioma; cerebellum; retrospective study; cross-sectional study; fmri; language; functional magnetic resonance imaging; hemispheric dominance; right hemisphere; brain size; plasticity; kernel method; prefrontal cortex; voxel based morphometry; gray matter; primary motor cortex; language test; human; male; female; article; head movement; superior temporal gyrus; inferior frontal gyrus; anterior cingulate; default mode network; fusiform gyrus; posterior cingulate; language reorganization; cortical volume; right hippocampus
Journal Title:	Cortex
Volume:	157
ISSN:	0010-9452
Publisher:	Elsevier Inc.
Date Published:	2022-12-01
Start Page:	245
End Page:	255
Language:	English
DOI:	10.1016/j.cortex.2022.09.014
PROVIDER:	scopus
PUBMED:	36356409
PMCID:	PMC10201933
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85141242929&doi=10.1016%2fj.cortex.2022.09.014&partnerID=40&md5=8833a9a1eebf1555506c0d0bb1d063a9
Notes:	Article -- Export Date: 1 December 2022 -- Source: Scopus

https://synapse.mskcc.org/synapse/works/has_related_data_chk/200413