Cognitive control network and language reorganization in patients with brain tumors Journal Article
| Authors: | Pasquini, L.; Napolitano, A.; Spitoni, L.; Schmid, M.; Dellepiane, F.; Jenabi, M.; Peck, K.; Holodny, A. |
| Article Title: | Cognitive control network and language reorganization in patients with brain tumors |
| Abstract: | BACKGROUND AND PURPOSE: The interaction between language and other cognitive networks in patients harboring brain tumors is poorly understood. We studied the modification of the cognitive control network (CCN) induced by brain tumors and its participation in language reorganization. We hypothesized that patients with brain tumors and reorganized language would show a modification of the CCN compared with patients who remain left dominant. MATERIALS AND METHODS: Patients were selected with the criteria: newly diagnosed, pathologically-confirmed left-hemispheric tumor; single lesions; right-handedness; task-based and resting-state fMRI; no artifacts. Age-matched healthy controls (HC) were recruited from open-source databases. Language laterality was calculated by using task-based fMRI. We obtained the CCN through ad hoc independent component analysis on resting-state fMRI. Differences in CCN between patients and HC were characterized by cosine similarity (CS) and earth mover’s distance (EMD). Changes related to language reorganization and patients’ speech were assessed with the t test (P < .05). Results were corrected for multiple comparisons. RESULTS: One hundred forty-two right-handed patients (35 low-grade and 88 high-grade gliomas; 19 metastases) and 184 HC were included. Two independent components of the CCN were obtained. The t test confirmed significant effects of lateralization on the CCN (P = .004). Modification of CCN was associated with fewer speech deficits 1 week after surgery (P = .005). CONCLUSIONS: This study provides evidence that modifications of CCN occur in the setting of language reorganization. Patients exhibiting these modifications perform better at speech evaluation after surgery, suggesting a role of cognitive control in compensating for speech deficits when language reorganizes. © 2025 American Society of Neuroradiology. All rights reserved. |
| Keywords: | adult; aged; middle aged; pathophysiology; nuclear magnetic resonance imaging; brain tumor; brain neoplasms; magnetic resonance imaging; cognition; language; hemispheric dominance; functional laterality; nerve cell network; nerve net; complication; procedures; humans; human; male; female |
| Journal Title: | American Journal of Neuroradiology |
| Volume: | 46 |
| Issue: | 6 |
| ISSN: | 0195-6108 |
| Publisher: | American Society of Neuroradiology |
| Date Published: | 2025-06-01 |
| Start Page: | 1238 |
| End Page: | 1248 |
| Language: | English |
| DOI: | 10.3174/ajnr.A8638 |
| PUBMED: | 39730156 |
| PROVIDER: | scopus |
| PMCID: | PMC12152808 |
| DOI/URL: | |
| Notes: | The MSK Cancer Center Support Grant (P30 CA008748) is acknowledge in the PDF -- Corresponding authors is MSK author: Luca Pasquini -- Source: Scopus |
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