Beyond T cells: IgA incites immune recognition in endometrial cancer Editorial
| Authors: | Osorio, J. C.; Zamarin, D. |
| Title: | Beyond T cells: IgA incites immune recognition in endometrial cancer |
| Abstract: | While T cells are established major players in antitumor immunity, tumor-associated B cells and antibodies have recently emerged as critical components in modulating immunity in the tumor microenvironment. In the current issue of Cancer Research, Mandal and colleagues show that tumor-infiltrating B cells are associated with improved outcomes in endometrial cancers. Mechanistically, the investigators demonstrate that the immune response is mediated by class-switched IgA binding to the polymeric immunoglobulin receptor in tumor cells, resulting in tumor cell–intrinsic activation of inflammatory pathways. These findings highlight that coordinated B-cell and T-cell responses may predict improved outcomes in patients with endometrial cancer and set the groundwork to further investigate the mechanisms by which humoral immunity could be exploited for cancer immunotherapy. © 2022 American Association for Cancer Research |
| Journal Title: | Cancer Research |
| Volume: | 82 |
| Issue: | 5 |
| ISSN: | 0008-5472 |
| Publisher: | American Association for Cancer Research |
| Date Published: | 2022-03-01 |
| Start Page: | 766 |
| End Page: | 768 |
| Language: | English |
| DOI: | 10.1158/0008-5472.Can-21-4385 |
| PUBMED: | 35247898 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 April 2022 -- Source: Scopus |
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