Negative regulators of T-cell activation: Potential targets for therapeutic intervention in cancer, autoimmune disease, and persistent infections Journal Article
| Authors: | Pentcheva-Hoang, T.; Corse, E.; Allison, J. P. |
| Article Title: | Negative regulators of T-cell activation: Potential targets for therapeutic intervention in cancer, autoimmune disease, and persistent infections |
| Abstract: | The generation of productive adaptive immune responses depends on the antigen-specific activation of T and B cells. The outcome of T-cell receptor engagement is influenced by signals from both positive and negative regulatory molecules that can either activate or inhibit T-cell function. CD28 and cytotoxic T-lymphocyte antigen-4 are the prototypical members of an immunoglobulin domain-containing protein family that play important roles in the control of T-cell responses against infection, cancer, and in autoimmune disease. Although the precise molecular details of their functions are still under active investigation, tumors and chronic pathogens seem to have exploited these pathways to achieve immune evasion. Furthermore, malfunction of the inhibitory arm of the immune response appears responsible for the development of multiple autoimmune pathologies. As a result, the negative regulators of T-cell activation have become attractive targets for therapeutic intervention in cancer, chronic infection, and autoimmune disease. The application of findings from basic research has provided insight into the manipulation of these pathways in the clinic and offers promising strategies for the treatment of disease. © 2009 John Wiley & Sons A/S. |
| Keywords: | signal transduction; protein expression; unclassified drug; clinical trial; review; cancer growth; drug potentiation; nonhuman; protein function; neoplasm; neoplasms; t-lymphocytes; animals; cell function; cytotoxic t lymphocyte antigen 4 antibody; melanoma; infection; granulocyte macrophage colony stimulating factor; b cell lymphoma; t lymphocyte receptor; t cell lymphoma; immunological tolerance; regulatory t lymphocyte; lymphocyte activation; hematologic malignancy; immunotherapy; drug mechanism; receptors, antigen, t-cell; ovary carcinoma; autoimmunity; rheumatoid arthritis; prostate adenocarcinoma; ctla-4; antigens, cd; indoleamine 2,3 dioxygenase; protein structure; adaptive immunity; cytotoxic t lymphocyte antigen 4; autoimmune diseases; autoimmune disease; glycoprotein; t lymphocyte activation; cd28 antigen; antigens, cd28; b7 antigen; cd86 antigen; btla; lag-3; pd-1; abatacept; b and t lymphocyte attenuator; cd160 antigen; ct 011; herpesvirus entry mediator; protein antibody; protein b7 h3; protein b7x; protein lag 3; protein pd 1; protein pd l1; protein pd l2; persistent infection; tryptophan metabolism; virus immunity |
| Journal Title: | Immunological Reviews |
| Volume: | 229 |
| Issue: | 1 |
| ISSN: | 0105-2896 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2009-05-01 |
| Start Page: | 67 |
| End Page: | 87 |
| Language: | English |
| DOI: | 10.1111/j.1600-065X.2009.00763.x |
| PUBMED: | 19426215 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 8" - "Export Date: 30 November 2010" - "CODEN: IMRED" - "Source: Scopus" |
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