Regulatory T cells: Mechanisms of differentiation and function Journal Article
| Authors: | Josefowicz, S. Z.; Lu, L. F. ; Rudensky, A. Y. |
| Article Title: | Regulatory T cells: Mechanisms of differentiation and function |
| Abstract: | The immune system has evolved to mount an effective defense against pathogens and to minimize deleterious immune-mediated inflammation caused by commensal microorganisms, immune responses against self and environmental antigens, and metabolic inflammatory disorders. Regulatory T (Treg) cellmediated suppression serves as a vital mechanism of negative regulation of immune-mediated inflammation and features prominently in autoimmune and autoinflammatory disorders, allergy, acute and chronic infections, cancer, and metabolic inflammation. The discovery that Foxp3 is the transcription factor that specifies the Treg cell lineage facilitated recent progress in understanding the biology of regulatory T cells. In this review, we discuss cellular and molecular mechanisms in the differentiation and function of these cells. © 2012 by Annual Reviews. All rights reserved. |
| Keywords: | autoimmunity; tolerance; foxp3; immune homeostasis |
| Journal Title: | Annual Review of Immunology |
| Volume: | 30 |
| ISSN: | 0732-0582 |
| Publisher: | Annual Reviews |
| Date Published: | 2012-01-01 |
| Start Page: | 531 |
| End Page: | 564 |
| Language: | English |
| DOI: | 10.1146/annurev.immunol.25.022106.141623 |
| PROVIDER: | scopus |
| PUBMED: | 22224781 |
| PMCID: | PMC6066374 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 1 May 2012" - "CODEN: ARIMD" - "Source: Scopus" |
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