The transcriptional regulator HDP1 controls expansion of the inner membrane complex during early sexual differentiation of malaria parasites Journal Article

   

Authors:	Campelo Morillo, R. A.; Tong, X.; Xie, W.; Abel, S.; Orchard, L. M.; Daher, W.; Patel, D. J.; Llinás, M.; Le Roch, K. G.; Kafsack, B. F. C.
Article Title:	The transcriptional regulator HDP1 controls expansion of the inner membrane complex during early sexual differentiation of malaria parasites
Abstract:	Transmission of Plasmodium falciparum and other malaria parasites requires their differentiation from asexual blood stages into gametocytes, the non-replicative sexual stage necessary to infect the mosquito vector. This transition involves changes in gene expression and chromatin reorganization that result in the activation and silencing of stage-specific genes. However, the genomes of malaria parasites have been noted for their limited number of transcriptional and chromatin regulators, and the molecular mediators of these changes remain largely unknown. We recently identified homeodomain protein 1 (HDP1) as a DNA-binding protein, first expressed in gametocytes, that enhances the expression of key genes critical for early sexual differentiation. The discovery of HDP1 marks a new class of transcriptional regulator in malaria parasites outside of the better-characterized ApiAP2 family. Here, using molecular biology, biochemistry and microscopy techniques, we show that HDP1 is essential for gametocyte maturation, facilitating the necessary upregulation of inner membrane complex components during early gametocytogenesis that gives P. falciparum gametocytes their characteristic shape. © 2022, The Author(s), under exclusive licence to Springer Nature Limited.
Keywords:	genetics; classification; homeodomain proteins; gene expression regulation; growth, development and aging; homeodomain protein; plasmodium falciparum; life cycle stages; protozoan proteins; sex differentiation; protozoal protein; life cycle stage
Journal Title:	Nature Microbiology
Volume:	7
Issue:	2
ISSN:	2058-5276
Publisher:	Nature Publishing Group
Date Published:	2022-02-01
Start Page:	289
End Page:	299
Language:	English
DOI:	10.1038/s41564-021-01045-0
PUBMED:	35087229
PROVIDER:	scopus
PMCID:	PMC8852293
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123799646&doi=10.1038%2fs41564-021-01045-0&partnerID=40&md5=11787e44afbda02cf4c780320467a633
Notes:	Article -- Erratum issued, see DOI: 10.1038/s41564-022-01082-3 -- Export Date: 1 March 2022 -- Source: Scopus

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