The polymorphic subtelomeric regions of Plasmodium falciparum chromosomes contain arrays of repetitive sequence elements Journal Article

   

Authors:	De Bruin, D.; Lanzer, M.; Ravetch, J. V.
Article Title:	The polymorphic subtelomeric regions of Plasmodium falciparum chromosomes contain arrays of repetitive sequence elements
Abstract:	The human malaria parasite Plasmodium falciparum exhibits a high degree of chromosomal polymorphism, which may contribute to its ability to evade host defenses. The analysis of parasite chromosomes has revealed that these polymorphisms are confined to the subtelomeric regions, which are transcriptionally silent and contain repetitive sequence elements. Several subtelomeric repetitive elements have been isolated and mapped by using P. falciparum yeast artificial chromosome (YAC) clones. Structural analysis of parasite telomeric and subtelomeric YAC clones demonstrated that these repetitive elements are conserved between P. falciparum chromosome ends. We suggest that these subtelomeric elements promote chromosome pairing in P. falciparum and facilitate meiotic recombination and gene conversion between telomere-proximal genes.
Keywords:	nonhuman; telomere; meiosis; gene conversion; genetic recombination; nucleotide sequence; host resistance; plasmodium falciparum; chromosome pairing; recombination; malaria; genome organization; priority journal; article; chromosome polymorphism
Journal Title:	Proceedings of the National Academy of Sciences of the United States of America
Volume:	91
Issue:	2
ISSN:	0027-8424
Publisher:	National Academy of Sciences
Date Published:	1994-01-18
Start Page:	619
End Page:	623
Language:	English
DOI:	10.1073/pnas.91.2.619
PROVIDER:	scopus
PMCID:	PMC43000
PUBMED:	8290573
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-0028120886&doi=10.1073%2fpnas.91.2.619&partnerID=40&md5=ccd5a4a24ea8d198f28449121c442e11
Notes:	Source: Scopus

https://synapse.mskcc.org/synapse/works/has_related_data_chk/138206