Human herpesvirus 6 DNAemia is associated with worse survival after ex vivo T-cell-depleted hematopoietic cell transplant Journal Article

   


Authors: Lee, Y. J.; Su, Y.; Cho, C.; Tamari, R.; Perales, M. A.; Jakubowski, A. A.; Papanicolaou, G. A.
Article Title: Human herpesvirus 6 DNAemia is associated with worse survival after ex vivo T-cell-depleted hematopoietic cell transplant
Abstract: BACKGROUND: We examined the correlation between persistent human herpesvirus 6 (HHV-6) DNAemia (p-HHV-6) and absolute lymphocyte count (ALC), platelet count (PLT), and all-cause mortality by 1 year after ex vivo T-cell-depleted (TCD) hematopoietic cell transplant (HCT). METHODS: We analyzed a cohort of adult TCD HCT recipients during 2012-2016 prospectively monitored for plasma HHV-6 by quantitative polymerase chain reaction from day +14 post-HCT through day +100 (D+100). p-HHV-6 was defined as ≥2 consecutive values of ≥500 copies/mL by D+100. PLT and ALC were compared between patients with and without p-HHV-6 using generalized estimating equations (GEE). Multivariable Cox proportional hazard models (PH) were used to identify the impact of p-HHV-6 on 1 year mortality. RESULTS: Of 312 patients, 83 (27%) had p-HHV-6 by D+100. p-HHV-6 was associated with lower ALC and PLT in the first year post-HCT. In multivariable models, p-HHV-6 was associated with higher mortality by 1 year post-HCT (adjusted hazard ratio, 2.97 [95% confidence interval, 1.62-5.47]; P = .0005), after adjusting for age, antiviral treatment, and ALC at D+100. CONCLUSIONS: p-HHV-6 was associated with lower ALC and PLT in the first year post-HCT. p-HHV-6 was an independent predictor of mortality in the first year after TCD HCT. © The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.
Keywords: adult; controlled study; human tissue; human cell; mortality; nonhuman; cohort analysis; hematopoietic cell; t cell depletion; ex vivo study; analysis of variance; graft recipient; platelet count; antiviral therapy; t-cell depletion; hematopoietic cell transplant; absolute lymphocyte count; human; male; female; article; human herpesvirus 6; all cause mortality
Journal Title: Journal of Infectious Diseases
Volume: 225
Issue: 3
ISSN: 0022-1899
Publisher: Oxford University Press  
Date Published: 2022-02-01
Start Page: 453
End Page: 464
Language: English
DOI: 10.1093/infdis/jiab412
PUBMED: 34390240
PROVIDER: scopus
PMCID: PMC8807153
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123968806&doi=10.1093%2finfdis%2fjiab412&partnerID=40&md5=e6b1b48ac4813181a316e4d6761a582f
Notes: Article -- Export Date: 1 March 2022 -- Source: Scopus
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MSK Authors
  1. Yeon Joo Lee
    50 Lee
  2. Genovefa A Papanicolaou
    238 Papanicolaou
  3. Ann Jakubowski
    455 Jakubowski
  4. Miguel-Angel Perales
    913 Perales
  5. Christina Cho
    134 Cho
  6. Roni Tamari
    208 Tamari
  7. Yiqi Su
    20 Su
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