Adenovirus viral kinetics and mortality in ex vivo T cell-depleted hematopoietic cell transplant recipients with adenovirus infection from a single center Journal Article

   


Authors: Lee, Y. J.; Fang, J.; Zavras, P. D.; Prockop, S. E.; Boulad, F.; Tamari, R.; Perales, M. A.; Papadopoulos, E. B.; Jakubowski, A. A.; Giralt, S. A.; Papanicolaou, G. A.
Article Title: Adenovirus viral kinetics and mortality in ex vivo T cell-depleted hematopoietic cell transplant recipients with adenovirus infection from a single center
Abstract: BACKGROUND: We report on predictors of adenovirus (ADV) viremia and correlation of ADV viral kinetics with mortality in ex vivo T-cell depleted (TCD) hematopoietic cell transplant (HCT). METHODS: T cell-depleted HCT recipients from January 1, 2012 through September 30, 2018 were prospectively monitored for ADV in the plasma through Day (D) +100 posttransplant or for 16 weeks after the onset of ADV viremia. Adenovirus viremia was defined as ≥2 consecutive viral loads (VLs) ≥1000 copies/mL through D +100. Time-averaged area under the curve (AAUC) or peak ADV VL through 16 weeks after onset of ADV viremia were explored as predictors of mortality in Cox models. RESULTS: Of 586 patients (adult 81.7%), 51 (8.7%) developed ADV viremia by D +100. Age <18 years, recipient cytomegalovirus seropositivity, absolute lymphocyte count <300 cells/μL at D +30, and acute graft-versus-host disease were predictors of ADV viremia in multivariate models. Fifteen (29%) patients with ADV viremia died by D +180; 8 of 15 (53%) died from ADV. Peak ADV VL (hazard ratio [HR], 2.25; 95% confidence interval [CI], 1.52-3.33) and increasing AAUC (HR, 2.95; 95% CI, 1.83-4.75) correlated with mortality at D +180. CONCLUSIONS: In TCD HCT, peak ADV VL and ADV AAUC correlated with mortality at D +180. Our data support the potential utility of ADV viral kinetics as endpoints in clinical trials of ADV therapies. © The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.
Keywords: adenovirus infection; hematopoietic cell transplant; viral kinetics
Journal Title: Journal of Infectious Diseases
Volume: 222
Issue: 7
ISSN: 0022-1899
Publisher: Oxford University Press  
Date Published: 2020-10-01
Start Page: 1180
End Page: 1187
Language: English
DOI: 10.1093/infdis/jiaa237
PUBMED: 32374872
PROVIDER: scopus
PMCID: PMC7459134
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85090178686&doi=10.1093%2finfdis%2fjiaa237&partnerID=40&md5=783854a14fd4e3ff9a31c6752ee5e20d
Notes: Article -- Source: Scopus
Altmetric
What is Altmetric?
Citation Impact
What is Dimensions Citation Badge?
BMJ Impact Analytics
MSK Authors
  1. Farid Boulad
    329 Boulad
  2. Susan E Prockop
    262 Prockop
  3. Yeon Joo Lee
    50 Lee
  4. Sergio Andres Giralt
    1050 Giralt
  5. Genovefa A Papanicolaou
    238 Papanicolaou
  6. Esperanza B Papadopoulos
    415 Papadopoulos
  7. Ann Jakubowski
    455 Jakubowski
  8. Miguel-Angel Perales
    913 Perales
  9. Roni Tamari
    208 Tamari
  10. Faidon Zavras
    11 Zavras
  11. Jiaqi Fang
    9 Fang
Related MSK Work