Promoting spliceosome assembly for therapeutic intent Editorial
| Authors: | Lu, B.; Abdel-Wahab, O. |
| Title: | Promoting spliceosome assembly for therapeutic intent |
| Abstract: | RNA splicing, the process by which precursor mRNA (pre-mRNA) is processed to mature mRNA, is catalyzed by the spliceosome. Recently, Chatrikhi et al. identified pharmacologic means to perturb splicing by enhancing the spliceosome's binding to pre-mRNA. This represents a novel chemical target and mechanism for therapeutic modulation of splicing. © 2021 Elsevier Ltd |
| Keywords: | rna; myelodysplastic syndromes; splicing; sf3b1; u2af1; rbm39 |
| Journal Title: | Trends in Pharmacological Sciences |
| Volume: | 42 |
| Issue: | 12 |
| ISSN: | 0165-6147 |
| Publisher: | Cell Press |
| Date Published: | 2021-12-01 |
| Start Page: | 981 |
| End Page: | 983 |
| Language: | English |
| DOI: | 10.1016/j.tips.2021.09.006 |
| PUBMED: | 34602305 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Short Survey -- Export Date: 1 December 2021 -- Source: Scopus |
