SnapShot: Splicing alterations in cancer Miscellaneous
| Authors: | Rahman, M. A.; Krainer, A. R.; Abdel-Wahab, O. |
| Title: | SnapShot: Splicing alterations in cancer |
| Abstract: | RNA splicing, the spliceosome-catalyzed process by which pre-messenger RNA (pre-mRNA) is processed to mature mRNA, is altered in a number of ways in cancer. Tumor-specific splicing alterations are created by mutations that disrupt splicing-regulatory elements within genes and impair splicing recognition or by altering the RNA-binding preferences of individual splicing factors. This SnapShot summarizes our current understanding of splicing-factor alterations in cancers. To view this SnapShot, open or download the PDF. © 2019 Elsevier Inc. |
| Keywords: | signal transduction; mutation; phosphorylation; cancer therapy; protein processing; messenger rna; gene control; catalysis; codon; spliceosome; rna binding; rna splicing; dna rna hybridization; priority journal; article; rna splicing factor; rna recognition motif; malignant neoplasm |
| Journal Title: | Cell |
| Volume: | 180 |
| Issue: | 1 |
| ISSN: | 0092-8674 |
| Publisher: | Cell Press |
| Date Published: | 2020-01-09 |
| Start Page: | 208 |
| End Page: | 208.e1 |
| Language: | English |
| DOI: | 10.1016/j.cell.2019.12.011 |
| PUBMED: | 31951519 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Source: Scopus |
