U1 snrnp-dependent suppression of polyadenylation: Physiological role and therapeutic opportunities in cancer Journal Article


Authors: Spraggon, L.; Cartegni, L.
Article Title: U1 snrnp-dependent suppression of polyadenylation: Physiological role and therapeutic opportunities in cancer
Abstract: Pre-mRNA splicing and polyadenylation are critical steps in the maturation of eukaryotic mRNA. U1 snRNP is an essential component of the splicing machinery and participates in splice-site selection and spliceosome assembly by base-pairing to the 5′ splice site. U1 snRNP also plays an additional, nonsplicing global function in 3′ end mRNA processing; it actively suppresses the polyadenylation machinery from using early, mostly intronic polyadenylation signals which would lead to aberrant, truncated mRNAs. Thus, U1 snRNP safeguards pre-mRNA transcripts against premature polyadenylation and contributes to the regulation of alternative polyadenylation. Here, we review the role of U1 snRNP in 3′ end mRNA processing, outline the evidence that led to the recognition of its physiological, general role in inhibiting polyadenylation, and finally highlight the possibility of manipulating this U1 snRNP function for therapeutic purposes in cancer. © 2013 Lee Spraggon and Luca Cartegni.
Keywords: review; neoplasm; genetic association; cancer therapy; 3' untranslated region; spliceosome; rna processing; small nuclear ribonucleoprotein; messenger rna precursor; deregulation; polyadenylation; priority journal
Journal Title: International Journal of Cell Biology
Volume: 2013
Issue: Article ID 846510
ISSN: 1687-8876
Publisher: Lee Spraggon and Luca Cartegni  
Date Published: 2013-01-01
Start Page: 1
End Page: 10
Language: English
DOI: 10.1155/2013/846510
PROVIDER: scopus
PMCID: PMC3826338
PUBMED: 24285958
DOI/URL:
Notes: Export Date: 2 January 2014 -- Source: Scopus
Altmetric
Citation Impact
MSK Authors