The presence of non-hepatic malignancy and its implication in pursuing liver transplantation Review
| Authors: | Chayanupatkul, M.; Gambarin-Gelwan, M.; Schiano, T. D. |
| Review Title: | The presence of non-hepatic malignancy and its implication in pursuing liver transplantation |
| Abstract: | Background: Primary extrahepatic malignancy and chronic liver disease co-exist in a considerable number of patients, creating a dilemma both in the aspects of liver transplant candidacy and cancer therapy. In this review, we will explore several aspects and controversies of liver transplantation in patients with non-hepatocellular carcinoma malignancy including risks of cancer recurrence after liver transplantation and the ethical dilemma of the selection of liver transplantation candidates with non-hepatic malignancy. Methods: We performed a search in several online databases and reviewed published articles and ongoing clinical trials in the topics of transplantation and pre-existing malignancies. Results and Discussion: Liver transplantation can be safely performed in selected patients with pre-existing extrahepatic malignancies with low recurrence rate if they have an expected 5-year survival rate of at least 50%. The cancer-free period before transplantation depends on the type, stage, and location of cancer. A shorter or no wait-time may be considered in an early stage cancer or carcinoma in situ. The urgency and benefits of liver transplantation should also be taken into consideration when determining a reasonable wait-time. This is particularly important in patients with decompensated cirrhosis who cannot afford to wait a few years before they can undergo liver transplantation. © 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. |
| Keywords: | liver transplantation; chemotherapy; neoplasm; outcome; malignancy |
| Journal Title: | Clinical Transplantation |
| Volume: | 35 |
| Issue: | 10 |
| ISSN: | 0902-0063 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2021-10-01 |
| Start Page: | e14410 |
| Language: | English |
| DOI: | 10.1111/ctr.14410 |
| PUBMED: | 34189778 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Export Date: 1 December 2021 -- Source: Scopus |
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