WNT as a driver and dependency in cancer Review
| Authors: | Parsons, M. J.; Tammela, T.; Dow, L. E. |
| Review Title: | WNT as a driver and dependency in cancer |
| Abstract: | The WNT signaling pathway is a critical regulator of development and adult tissue homeostasis and becomes dysregulated in many cancer types. Although hyperac-tivation of WNT signaling is common, the type and frequency of genetic WNT pathway alterations can vary dramatically between different cancers, highlighting possible cancer-specific mechanisms for WNT-driven disease. In this review, we discuss how WNT pathway disruption contributes to tumorigen-esis in different organs and how WNT affects the tumor cell and immune microenvironment. Finally, we describe recent and ongoing efforts to target oncogenic WNT signaling as a therapeutic strategy. Significance: WNT signaling is a fundamental regulator of tissue homeostasis and oncogenic driver in many cancer types. In this review, we highlight recent advances in our understanding of WNT signaling in cancer, particularly the complexities of WNT activation in distinct cancer types, its role in immune evasion, and the challenge of targeting the WNT pathway as a therapeutic strategy. © 2021 American Association for Cancer Research. |
| Keywords: | protein phosphorylation; gene mutation; somatic mutation; review; cancer growth; liver cell carcinoma; pancreas cancer; colorectal cancer; cell proliferation; gene; cell survival; melanoma; apoptosis; multiple myeloma; breast cancer; cell infiltration; tumor volume; prevalence; lung cancer; tissue regeneration; cell differentiation; transcriptomics; protein p53; carcinogenesis; neuroendocrine tumor; prostate cancer; extracellular matrix; wound healing; liver metastasis; immunological tolerance; regulatory t lymphocyte; transcription regulation; ubiquitination; microsatellite instability; cancer stem cell; pancreas adenocarcinoma; stomach cancer; tumor immunity; upregulation; tumor growth; immunosuppressive treatment; homeostasis; ubiquitin protein ligase e3; k ras protein; beta catenin; wnt protein; rna polymerase ii; disease exacerbation; g protein coupled receptor; osteoclast differentiation factor; programmed death 1 ligand 1; non small cell lung cancer; tumor microenvironment; wnt signaling; immune evasion; epithelial mesenchymal transition; interleukin 23; acute myeloid leukemia; cell plasticity; ctnnb1 gene; human; rnf43 gene; malignant neoplasm; axin1 gene; rspo2 gene |
| Journal Title: | Cancer Discovery |
| Volume: | 11 |
| Issue: | 10 |
| ISSN: | 2159-8274 |
| Publisher: | American Association for Cancer Research |
| Date Published: | 2021-10-01 |
| Start Page: | 2413 |
| End Page: | 2429 |
| Language: | English |
| DOI: | 10.1158/2159-8290.Cd-21-0190 |
| PROVIDER: | scopus |
| PMCID: | PMC8487948 |
| PUBMED: | 34518209 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 1 December 2021 -- Source: Scopus |
