Wnt signaling pathways meet Rho GTPases Journal Article
| Authors: | Schlessinger, K.; Hall, A.; Tolwinski, N. |
| Article Title: | Wnt signaling pathways meet Rho GTPases |
| Abstract: | Wnt ligands and their receptors orchestrate many essential cellular and physiological processes. During development they control differentiation, proliferation, migration, and patterning, while in the adult, they regulate tissue homeostasis, primarily through their effects on stem cell proliferation and differentiation. Underpinning these diverse biological activities is a complex set of intracellular signaling pathways that are still poorly understood. Rho GTPases have emerged as key mediators of Wnt signals, most notably in the noncanonical pathways that involve polarized cell shape changes and migrations, but also more recently in the canonical pathway leading to β-catenin-dependent transcription. It appears that Rho GTPases integrate Wnt-induced signals spatially and temporally to promote morphological and transcriptional changes affecting cell behavior. © 2009 by Cold Spring Harbor Laboratory Press. |
| Keywords: | signal transduction; gene mutation; human cell; mutation; review; nonhuman; cell proliferation; animal cell; mouse; animals; actin; cell division; models, biological; mitogen activated protein kinase p38; embryo; drosophila; embryo development; genetic transcription; cell differentiation; neurons; enzyme activation; hela cell; cell migration; cell movement; cell polarity; mitosis spindle; protein kinase c; caenorhabditis elegans; cell shape; wnt proteins; mammals; beta catenin; myosin; wnt protein; nervous system development; cytoskeleton; rho gtpases; rho guanine nucleotide binding protein; rho gtp-binding proteins; zebra fish; zebrafish; heart development; protein cdc42; rac protein; planar cell polarity; eye development; canonical wnt signaling; noncanonical wnt signaling; polarity; wnt; frizzled protein; heterotrimeric guanine nucleotide binding protein; rho kinase; chick embryo; forelimb; gastrulation; mammal cell; xenopus laevis; chickens |
| Journal Title: | Genes and Development |
| Volume: | 23 |
| Issue: | 3 |
| ISSN: | 0890-9369 |
| Publisher: | Cold Spring Harbor Laboratory Press |
| Date Published: | 2009-02-01 |
| Start Page: | 265 |
| End Page: | 277 |
| Language: | English |
| DOI: | 10.1101/gad.1760809 |
| PUBMED: | 19204114 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 22" - "Export Date: 30 November 2010" - "CODEN: GEDEE" - "Source: Scopus" |
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