Rho family GTPases Journal Article

Author: Hall, A.
Article Title: Rho family GTPases
Abstract: Rho GTPases comprise a family of molecular switches that control signal transduction pathways in eukaryotic cells. A conformational change induced upon binding GTP promotes an interaction with target (effector) proteins to generate a cellular response. A highly conserved function of Rho GTPases from yeast to humans is to control the actin cytoskeleton, although, in addition, they promote a wide range of other cellular activities. Changes in the actin cytoskeleton drive many dynamic aspects of cell behaviour, including morphogenesis, migration, phagocytosis and cytokinesis, and the dysregulation of Rho GTPases is associated with numerous human diseases and disorders. ©The Authors Journal compilation ©2012 Biochemical Society.
Keywords: signal transduction; nonhuman; conference paper; protein function; cytology; cell function; morphogenesis; cell migration; conformational transition; cell shape; phagocytosis; cell activity; rho guanine nucleotide binding protein; protein cdc42; cytokinesis; gtpase; cdc42; rho; actin filament; rac; actin cytoskeleton; serum response factor; reduced nicotinamide adenine dinucleotide phosphate oxidase
Journal Title: Biochemical Society Transactions
Volume: 40
Issue: 6
ISSN: 0300-5127
Publisher: Portland Press Ltd  
Date Published: 2012-12-01
Start Page: 1378
End Page: 1382
Language: English
DOI: 10.1042/bst20120103
PROVIDER: scopus
PUBMED: 23176484
Notes: --- - "Export Date: 2 January 2013" - "CODEN: BCSTB" - "Source: Scopus"
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  1. Alan Hall
    38 Hall