Germ-line chromosomal localization of human C-Erb-A oncogene Journal Article
| Authors: | Jhanwar, S. C.; Chaganti, R. S. K.; Croce, C. M. |
| Article Title: | Germ-line chromosomal localization of human C-Erb-A oncogene |
| Abstract: | The human germ-line position of c-erb-A, the cellular counterpart of v-erb-A, has been determined by in situ molecular hybridization of a3H-labeled c-onc gene probe to meiotic pachytene chromosomes. Both v-erb-A and v-erb-B are the v-onc genes that are associated with induction of sarcoma and erythroblastosis in chicken by the avian erythroblastosis virus, a rapidly transforming RNA tumor virus. The position of c-erb-A, determined here to be at 17q21.33-q22, is in the same region of chromosome 17 in which a nonrandom break occurs in the generation of t(15;17), a translocation commonly seen in acute promyelocytic leukemia. © 1985 Plenum Publishing Corporation. |
| Keywords: | human cell; comparative study; pachytene; cytology; spermatocytes; heredity; oncogenes; in situ hybridization; gene mapping; germ line; oncogene; genetic engineering; radioisotope; gene location; normal human; chromosome 17q; retrovirus; chromosome mapping; male genital system; chromosomes, human, 16-18; normal value; human; male; support, u.s. gov't, p.h.s.; dna probe; translocation (genetics); chromosomes, human, 13-15 |
| Journal Title: | Somatic Cell and Molecular Genetics |
| Volume: | 11 |
| Issue: | 1 |
| ISSN: | 0740-7750 |
| Publisher: | Springer New York LLC |
| Date Published: | 1985-01-01 |
| Start Page: | 99 |
| End Page: | 102 |
| Language: | English |
| DOI: | 10.1007/bf01534740 |
| PROVIDER: | scopus |
| PUBMED: | 3856334 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 26 October 2021 -- Source: Scopus |
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