Effect of estrogen and androgen administration on α‐difluoro‐methylornithine‐enhanced putrescine uptake by the rat prostate Journal Article
| Authors: | Kadmon, D.; Mahle, C.; Heston, W. D. W.; Hahn, D. A. |
| Article Title: | Effect of estrogen and androgen administration on α‐difluoro‐methylornithine‐enhanced putrescine uptake by the rat prostate |
| Abstract: | Radiolabeled putrescine is a potential imaging agent for carcinoma of the prostate. The intrinsically high uptake of putrescine into the rat prostate and prostatic carcinoma can be further stimulated by pretreatment of the animals with α‐difluoromethylornithine (DFMO) uptake, a polyamine synthesis inhibitor. Pharmacological castration of the animals followed by androgen stimulation and DFMO pretreatment achieved a 30:1 prostate/muscle ratio of 14C‐putrescine uptake in elderly rats. Copyright © 1985 Wiley‐Liss, Inc., A Wiley Company |
| Keywords: | nonhuman; animal; animal experiment; prostate; eflornithine; rat; rats; diethylstilbestrol; drug metabolism; castration; androstanolone; ornithine; prostate carcinoma; endocrine system; polyamines; rats, inbred strains; male genital system; putrescine; male; support, u.s. gov't, p.h.s.; stanolone; putrescine c 14; alpha‐difluoromethylornithine; dihydrotestosterone propionate; positron‐emitting transaxial tomography; androstanolone propionate; ornithine c 14 |
| Journal Title: | Prostate |
| Volume: | 6 |
| Issue: | 4 |
| ISSN: | 0270-4137 |
| Publisher: | John Wiley & Sons |
| Date Published: | 1985-01-01 |
| Start Page: | 343 |
| End Page: | 349 |
| Language: | English |
| DOI: | 10.1002/pros.2990060403 |
| PUBMED: | 3937149 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 26 October 2021 -- Source: Scopus |
