Chemotherapy and trace element levels in blood and tissue of rats implanted with prostate tumor cells Journal Article
| Authors: | Kuehn, K.; Dunzendorfer, U.; Whitmore, W. F.; Schrauzer, G. N. |
| Article Title: | Chemotherapy and trace element levels in blood and tissue of rats implanted with prostate tumor cells |
| Abstract: | Male Copenhagen rats with transplanted prostatic adeno-carcinoma were treated with different polyamine synthesis inhibitors, such as methylglyoxal-bis-guanylhydrazone (MGBG), erythro-9-(2-hydroxy-3-nonyl) adenine (EHNA) combined with 9-β-d-arabin-ofuranosyl-adenine (ARA-A), α-difluoromethyl-ornithine (DFMO), and some of their combinations. Levels of the essential trace elements-copper, zinc, magnesium, iron, selenium, and manganese -have been determined in blood, tumor, kidney, and liver of these animals and are discussed in terms of efficiency of the treatment. MGBG had the strongest effect on trace element levels in tissues of treated animals. MGBG combined with DFMO exhibited the highest antitumor activity of all treatment protocols. Selenium given as selenite with drinking water was used as an adjuvant with the most toxic combination, (ARA-A/EHNA, MGBG). Selenite reduced the toxicity of these therapeutic agents. © 1985 The Humana Press Inc. |
| Keywords: | cancer chemotherapy; nonhuman; chemotherapy; animal experiment; animal model; prostate cancer; eflornithine; rat; drug toxicity; selenium; drug cytotoxicity; trace element; therapy; vidarabine; mitoguazone; blood level; intoxication; tumor markers; intraperitoneal drug administration; male genital system; blood and hemopoietic system; sodium selenite; polyamine synthesis inhibitors; trace elements and cancer therapy; trace elements, antitumor activity; trace elements, levels in tissues; 9 (2 hydroxy 3 nonyl)adenine |
| Journal Title: | Biological Trace Element Research |
| Volume: | 8 |
| Issue: | 4 |
| ISSN: | 0163-4984 |
| Publisher: | Springer |
| Date Published: | 1985-12-01 |
| Start Page: | 237 |
| End Page: | 250 |
| Language: | English |
| DOI: | 10.1007/bf02989579 |
| PROVIDER: | scopus |
| PMCID: | 24258014 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 26 October 2021 -- Source: Scopus |
