2'-fluoro-5-iodoarabinosylcytosine, a new potent antiviral agent: Efficacy in immunosuppressed individuals with herpes zoster Journal Article
| Authors: | Leyland-Jones, B.; Donnelly, H.; Groshen, S.; Myskowski, P.; Donner, A. L.; Fanucchi, M.; Fox, J.; and the Memorial Sloan-Kettering Antiviral Working Group |
| Contributors: | Lopez, C.; Young, C. W.; Philips, F. S.; Brown, A. E.; Gold, J.; Armstrong, D.; Watanabe, K. A.; Safai, B.; Burchenal, J. H.; Price, R.; Clarkson, B. D. |
| Article Title: | 2'-fluoro-5-iodoarabinosylcytosine, a new potent antiviral agent: Efficacy in immunosuppressed individuals with herpes zoster |
| Abstract: | 2'-Fluoro-5-iodoarabinosylcytosine (FIAC) has potent antiviral activity in vivo against herpes simplex virus types 1 and 2 and cytomegalovirus. For examination of the clinical efficacy of FIAC, a randomized, double-blind study of FIAC versus adenine arabinoside (ara-A) was conducted in 34 immunosuppressed individuals with varicella-zoster virus infections. The median time to the appearance of the last new lesion was shorter in patients who received FIAC relative to those who received ara-A (two versus five days, respectively; P <.001) FIAC also reduced pain and accelerated initial crusting within 72 hr in a significantly greater proportion of patients when compared with ara-A (P =.004 and P =.0009, respectively). FIAC caused few toxic reactions (mild nausea and transient elevation in activity of serum aspartate aminotransferase). Thus FIAC is therapeutically superior to ara-A for the treatment of varicella-zoster virus infections in immunosuppressed subjects. © 1986 Oxford University Press. |
| Keywords: | adolescent; adult; child; clinical article; aged; middle aged; drug efficacy; cytarabine; methodology; neoplasms; nausea; vomiting; herpes zoster; lymphatic system; immune tolerance; chemistry; antivirus agent; virus infection; drug therapy; immunosuppressive treatment; double-blind method; therapy; cytomegalovirus; clinical trials; vidarabine; antiviral agents; random allocation; varicella zoster virus; reticuloendothelial system; new drug; fiacitabine; humans; human; male; female; priority journal |
| Journal Title: | Journal of Infectious Diseases |
| Volume: | 154 |
| Issue: | 3 |
| ISSN: | 0022-1899 |
| Publisher: | Oxford University Press |
| Date Published: | 1986-09-01 |
| Start Page: | 430 |
| End Page: | 436 |
| Language: | English |
| DOI: | 10.1093/infdis/154.3.430 |
| PUBMED: | 3525694 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 18 August 2021 -- Source: Scopus |
