X-linkage of steroid sulphatase in the mouse is evidence for a functional Y-linked allele Journal Article
| Authors: | Keitges, E.; Rivest, M.; Siniscalco, M.; Gartler, S. M. |
| Article Title: | X-linkage of steroid sulphatase in the mouse is evidence for a functional Y-linked allele |
| Abstract: | In the human there is an X-linked gene affecting steroid sulphatase (STS) activity which, when deficient, is associated with X-linked congenital ichthyosis1,2. The gene (STS) is located on the distal tip of the short arm3-6 and is only partially inactivated when it is on the inactive X-chromosome7-10. In the mouse, the genetics of STS are not clear; the results of one study using XX:X0 oocyte comparisons indicated X-linkage11, but three other studies using STS variants have produced segregation data compatible with autosomal linkage of murine STS 12-14. Here we present the results of STS assays of crosses of deficient C3H/An male mice12 to normal X0 animals which demonstrate X-linkage of STS in the mouse and indirectly indicate the existence of a functional STS allele on the Y-chromosome which undergoes obligatory recombination during meiosis with the X-linked allele. © 1985 Nature Publishing Group. |
| Keywords: | nonhuman; animal cell; mouse; animal; meiosis; mice; heredity; biological model; mice, inbred strains; genetic recombination; recombination, genetic; x chromosome; x chromosome inactivation; linkage (genetics); genetic linkage; chromosome mapping; y chromosome; chromosome xp; egg; ichthyosis; sex chromosomes; x chromosome linkage; male; female; priority journal; support, u.s. gov't, p.h.s.; steryl sulfatase; sulfatases |
| Journal Title: | Nature |
| Volume: | 315 |
| Issue: | 6016 |
| ISSN: | 0028-0836 |
| Publisher: | Nature Publishing Group |
| Date Published: | 1985-05-16 |
| Start Page: | 226 |
| End Page: | 227 |
| Language: | English |
| DOI: | 10.1038/315226a0 |
| PROVIDER: | scopus |
| PUBMED: | 3858674 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 26 October 2021 -- Source: Scopus |
