Human leukocyte antigen associations in basal cell carcinoma Journal Article
| Authors: | Myskowski, P. L.; Pollack, M. S.; Schorr, E.; Dupont, B.; Safai, B. |
| Article Title: | Human leukocyte antigen associations in basal cell carcinoma |
| Abstract: | Basal cell carcinoma is the most common form of skin cancer and is one in which both host and environmental factors are thought to play a role in its pathogenesis. For an investigation of the role of human leukocyte antigen (HLA)-associated variations in genetic susceptibility, thirty-one patients with multiple basal cell carcinomas were typed for HLA-A, B, C, and DR antigens. Patients were compared with both local and appropriate ethnic group controls. No statistically significant association with HLA-A, B, or C antigens was noted in any group. However, a significant increase in HLA-DR1 was noted in non-Irish, non-Ashkenazi patients. A tendency toward a decrease in HLA-DR3 was also noted among patients of Irish or Ashkenazi Jewish descent. The role of HLA-associated genetic factors in this form of skin cancer needs further investigation. © 1985, American Academy of Dermatology, Inc.. All rights reserved. |
| Keywords: | human cell; classification; basal cell carcinoma; histology; diagnosis; hla antigen; lymphocytotoxicity; intoxication; human; priority journal; ethnic or racial aspects; preliminary communication |
| Journal Title: | Journal of the American Academy of Dermatology |
| Volume: | 12 |
| Issue: | 6 |
| ISSN: | 0190-9622 |
| Publisher: | Mosby Elsevier |
| Date Published: | 1985-06-01 |
| Start Page: | 997 |
| End Page: | 1000 |
| Language: | English |
| DOI: | 10.1016/s0190-9622(85)70127-2 |
| PROVIDER: | scopus |
| PUBMED: | 3874217 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 26 October 2021 -- Source: Scopus |
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