Human neuroblastoma cells and 13-cis-retinoic acid Journal Article
| Authors: | Helson, L.; Helson, C. |
| Article Title: | Human neuroblastoma cells and 13-cis-retinoic acid |
| Abstract: | To a limited extent, we corroborated a previous report of human neuroblastoma sensitivity to 13-cis-retinoic acid. Seven cultured human neuroblastoma, two primitive neuroectodermal tumor, and one melanoma cell line were exposed to 0.001 to 10.0 o M 13-cis-retinoic acid for six to fourteen days. The neuroblastoma cell line, SK-N-DZ, was the only cell line lysed by all concentrations of 13-cis-retinoic acid. The other cell lines were refractory to concentrations as high as 10 μM. Increased cell process formation was observed in three neuroblastoma, SK-N-SH, SK-N-BE, SK-N-LE, and one melanoma cell line. We conclude that sensitivity to 13-cis-retinoic acid is unevenly distributed among histogenetically similar tumors from different patients. © 1985 Martinus Nijhoff Publishers. |
| Keywords: | human cell; dose response; drug efficacy; cell survival; melanoma; cell line; in vitro study; neuroblastoma; drug response; cytolysis; neoplasms, germ cell and embryonal; isotretinoin; drug administration; drug sensitivity; neuroectoderm tumor; therapy; primitive neuroectodermal tumor; nervous system; cell lysis; tretinoin; 13-cis-retinoic acid; tumor stem cell assay; human |
| Journal Title: | Journal of Neuro-Oncology |
| Volume: | 3 |
| Issue: | 1 |
| ISSN: | 0167-594X |
| Publisher: | Springer |
| Date Published: | 1985-03-01 |
| Start Page: | 39 |
| End Page: | 41 |
| Language: | English |
| DOI: | 10.1007/bf00165170 |
| PROVIDER: | scopus |
| PUBMED: | 2987426 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 26 October 2021 -- Source: Scopus |
