Anticlastogenic effects of 13-cis-retinoic acid in vitro Journal Article
| Authors: | Trizna, Z.; Hsu, T. C.; Schantz, S. P.; Jack Lee, J.; Hong, W. K. |
| Article Title: | Anticlastogenic effects of 13-cis-retinoic acid in vitro |
| Abstract: | The anticlastogenic effects of 13-cis-retinoic acid were studied in four human lymphoblastoid cell lines and in primary lymphocyte cultures derived from the peripheral blood of 11 study subjects. Cells were pre-incubated with 13-cis-retinoic acid in the concentration range of 10-8-10-5 mol/l for 24 h and the numbers of chromatid breaks per cell induced by bleomycin were determined. The presence of 13-cis-retinoic acid decreased the number of breaks per cell by 13.0 to 59.5% in lymphoblastoid cell lines and by 0 to 57.4% in primary lymphocyte cultures (in the concentration ranges of 10-8-10-6 mol/l and of 10-8-10-5 mol/l, respectively). Regression analysis showed that there was a statistically significant correlation between the presence of 13-cis-retinoic acid and protection against bleomycin-induced clastogenicity. These data give additional information to the knowledge of possible chemopreventive mechanisms of action of 13-cis-retinoic acid. © 1992. |
| Keywords: | clinical article; controlled study; human cell; chemoprophylaxis; dose-response relationship, drug; tumor cells, cultured; bleomycin; chromosome breakage; isotretinoin; lymphocytes; chromosomes; lymphoblastoid cell line; lymphocyte culture; human; male; female; priority journal; article; support, non-u.s. gov't; antimutagenic agents; bleomycin sulfate |
| Journal Title: | European Journal of Cancer |
| Volume: | 29 |
| Issue: | 1 |
| ISSN: | 0959-8049 |
| Publisher: | Elsevier Inc. |
| Date Published: | 1993-01-01 |
| Start Page: | 137 |
| End Page: | 140 |
| Language: | English |
| DOI: | 10.1016/0959-8049(93)90592-4 |
| PUBMED: | 1280151 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Source: Scopus |
