Synergistic effects of 13-cis retinoic acid and arachidonic acid cascade inhibitors on growth of head and neck squamous cell carcinoma in vitro Journal Article

  

Authors:	Spingarn, A.; Sacks, P. G.; Kelley, D.; Dannenberg, A. J.; Schantz, S. P.
Article Title:	Synergistic effects of 13-cis retinoic acid and arachidonic acid cascade inhibitors on growth of head and neck squamous cell carcinoma in vitro
Abstract:	Products of arachidonic acid metabolism can influence normal and malignant cell growth. In vivo, inhibitors of arachidonic acid metabolism have been associated with inhibition of tumor growth, including head and neck squamous cell carcinoma (HNSCC). This has not been evaluated extensively in vitro in an HNSCC model. Therefore we investigated the effects of several arachidonic acid cascade inhibitors (AACIs) (indomethacin, curcumin, phenidone, nordihydrogualaretic acid, 5,8,11,14-eicasatetraynoic acid, and 13-cisretinoic acid) on the growth of two HNSCC cell lines (MDA 886Ln and 1483). We found that AACIs caused dose-dependent growth inhibition of both cell lines. In an effort to inhibit HNSCC cell growth at lower concentrations of these drugs, we evaluated the effects of a variety of AACIs in combination with 13-cis retinoic acid. We observed synergistic growth inhibition when the drugs were used in all combinations, with the exception of indomethacin. These results suggest that AACIs may have some utility in the direct treatment of HNSCC, and a strategy combining 13-cis retinoic acid with other AACIs may prove to be even more effective.
Keywords:	squamous cell carcinoma; carcinoma, squamous cell; dose response; drug efficacy; drug potentiation; cell division; antineoplastic activity; drug effect; tumor cells, cultured; drug synergism; immunoenzyme techniques; cancer inhibition; head and neck cancer; head and neck neoplasms; indometacin; isotretinoin; arachidonic acid; prostaglandins e; curcumin; tretinoin; nordihydroguaiaretic acid; cyclooxygenase inhibitors; humans; human; article; phenidone; arachidonic acid metabolism
Journal Title:	Otolaryngology - Head and Neck Surgery
Volume:	118
Issue:	2
ISSN:	0194-5998
Publisher:	Sage Publications
Date Published:	1998-02-01
Start Page:	159
End Page:	164
Language:	English
DOI:	10.1016/s0194-5998(98)80004-1
PUBMED:	9482545
PROVIDER:	scopus
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-0031916806&doi=10.1016%2fS0194-5998%2898%2980004-1&partnerID=40&md5=4548ce937b4cfa10ef35fff7ebe58b09
Notes:	Article -- Export Date: 12 December 2016 -- Source: Scopus

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