Synthesis of [(13)N]cisplatin Journal Article
| Authors: | Haber, M. T.; Cooper, A. J. L.; Rosenspire, K. C.; Ginos, J. Z.; Rottenberg, D. A. |
| Article Title: | Synthesis of [(13)N]cisplatin |
| Abstract: | A method for the “carrier‐added” synthesis of [13N]cisplatin is described. Yields were ∼1–4 mCi from 20–40 mCi of [13N]ammonia with a total synthesis time of 19–28 minutes. The product was ∼96% radiochemically pure as judged by HPLC analysis and had a specific activity of ∼100 mCi/mmole in 1.0 ml of saline. [13N]Cisplatin was administered intraperitoneally to mice. Of the tissues investigated, concentration of label was highest in kidneys. At 10 min, considerable label in the blood, liver, and kidney was in a form other than cisplatin. However, no evidence was obtained that [13N]ammonia was released from [13N]cisplatin in vivo. [13N]Cisplatin may be used to assess drug delivery to primary and metastatic brain tumors in patients receiving intravenous or intraarterial cisplatin chemotherapy. Copyright © 1985 John Wiley & Sons, Ltd. |
| Keywords: | nonhuman; mouse; animal experiment; drug synthesis; liver; kidney; drug distribution; brain; drug tissue level; drug monitoring; drug blood level; high performance liquid chromatography; radioisotope; pharmacokinetics; muscle; nervous system; drug identification; intraperitoneal drug administration; priority journal; preliminary communication; blood and hemopoietic system; drug analysis; cisplatin n 13; [13n]ammonia; [13n]cisplatin |
| Journal Title: | Journal of Labelled Compounds and Radiopharmaceuticals |
| Volume: | 22 |
| Issue: | 5 |
| ISSN: | 0362-4803 |
| Publisher: | Wiley Blackwell |
| Date Published: | 1985-05-01 |
| Start Page: | 509 |
| End Page: | 516 |
| Language: | English |
| DOI: | 10.1002/jlcr.2580220512 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Note -- Export Date: 26 October 2021 -- Source: Scopus |
