Production and response to interleukin 2 in vitro and in vivo after bone marrow transplantation in mice Journal Article
| Authors: | Merluzzi, V. J.; Welte, K.; Last-Barney, K.; Mertelsmann, R.; Souza, L.; Boone, T.; Savage, D. M.; Quinn, D.; O'Reilly, R. J. |
| Article Title: | Production and response to interleukin 2 in vitro and in vivo after bone marrow transplantation in mice |
| Abstract: | Lymphoid cells from bone marrow radiation chimeras do not produce normal levels of IL 2 but are capable of responding to IL 2 in mitogenic and cytotoxic assays in vitro. The administration of recombinant human IL 2 into host mice that have received allogeneic, H-2-compatible marrow did not enhance mortality. |
| Keywords: | unclassified drug; drug efficacy; nonhuman; mouse; animals; mice; interleukin 2; spleen; cell line; in vitro study; postoperative complications; lymphatic system; lymphocyte activation; t-lymphocytes, cytotoxic; cytotoxicity, immunologic; radioisotope; mice, inbred cba; disease models, animal; bone marrow transplantation; lymphocyte; interleukin-2; thymidine h 3; mice, inbred c3h; escherichia coli lipopolysaccharide; mice, inbred dba; concanavalin a; male; priority journal; article; mast-cell sarcoma; blood and hemopoietic system |
| Journal Title: | Journal of Immunology |
| Volume: | 134 |
| Issue: | 4 |
| ISSN: | 0022-1767 |
| Publisher: | The American Association of Immunologists, Inc |
| Date Published: | 1985-04-01 |
| Start Page: | 2426 |
| End Page: | 2430 |
| Language: | English |
| PROVIDER: | scopus |
| PUBMED: | 3919093 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 26 October 2021 -- Source: Scopus |
