13-cis-retinoic acid does not increase the true remission rate and the duration of true remission (induced by cytotoxic chemotherapy) in patients with chronic phase chronic myelogenous leukemia Journal Article

  

Authors:	Arlin, Z. A.; Mertelsmann, R.; Berman, E.; Gee, T.; Kurland, E.; Chaganti, R. S. K.; Jhanwar, S. C.; Moore, M. A. S.; Clarkson, B. D.
Article Title:	13-cis-retinoic acid does not increase the true remission rate and the duration of true remission (induced by cytotoxic chemotherapy) in patients with chronic phase chronic myelogenous leukemia
Abstract:	Treatment of chronic phase chronic myelogenous leukemia with hydroxyurea or busulfan rarely induces cytogenetic (true) remissions. Intensive chemotherapy induces brief true remissions in approximately 50% of patients. We added 13-cis-retinoic acid to daunorubicin, cytosine arabinoside, and thioguanine to determine if it could increase the incidence and duration of remission induced by cytotoxic chemotherapy. Of the 17 evaluable patients, one patient (6%) achieved complete remission, and seven patients (41%) achieved partial remissions. The median duration of remission was 1.6 months. We conclude that 13-cis-retinoic acid does not increase the incidence and duration of remission in chronic phase chronic myelogenous leukemia.
Keywords:	cancer chemotherapy; clinical article; busulfan; hydroxyurea; doxorubicin; cancer combination chemotherapy; drug efficacy; skin toxicity; cytarabine; liver toxicity; nausea; stomatitis; vomiting; chronic myeloid leukemia; gastrointestinal toxicity; cancer regression; daunorubicin; sepsis; isotretinoin; drug therapy; adverse drug reaction; mouth; therapy; tioguanine; hypertriglyceridemia; intravenous drug administration; oral drug administration; leukemia remission; cheilitis; intoxication; etretinate; human; priority journal; blood and hemopoietic system; keratoderma
Journal Title:	Journal of Clinical Oncology
Volume:	3
Issue:	4
ISSN:	0732-183X
Publisher:	American Society of Clinical Oncology
Date Published:	1985-04-01
Start Page:	473
End Page:	476
Language:	English
DOI:	10.1200/jco.1985.3.4.473
PROVIDER:	scopus
PUBMED:	3856630
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-0021922179&doi=10.1200%2fJCO.1985.3.4.473&partnerID=40&md5=03e770fe0b75a659ff77ceb2a98d7652
Notes:	Article -- Export Date: 26 October 2021 -- Source: Scopus

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