Deficient Concanavalin‐A‐induced suppressor‐cell activity in patients with bronchial asthma, allergic rhinitis and atopic dermatitis Journal Article

  


Authors: Hwang, K. C.; Fikrig, S. M.; Friedman, H. M.; Gupta, S.
Article Title: Deficient Concanavalin‐A‐induced suppressor‐cell activity in patients with bronchial asthma, allergic rhinitis and atopic dermatitis
Abstract: Concanavalin‐A (Con‐A)‐induced suppressor activity against the proliferative response of autologous lymphocytes to phytohaemagglutinin (PHA) was examined in the peripheral‐blood lymphocytes from fourteen patients with bronchial asthma, ten patients with allergic rhinitis and eleven patients with atopic dermatitis and compared with eleven simultaneously studied healthy normals. Eight of fourteen patients (57%) with bronchial asthma, eight of ten patients (80%) with allergic rhinitis and five of eleven patients (45%) with atopic dermatitis demonstrated deficient Con‐A‐induced suppressor function. Abnormal suppressor‐cell functions could play an important role in the pathogenesis of atopic states. Copyright © 1985, Wiley Blackwell. All rights reserved
Keywords: pathogenesis; comparative study; allergic rhinitis; lymphocyte activation; asthma; suppressor cell; in vitro; immunoglobulin e; etiology; rhinitis; olfactory system; respiratory system; atopic dermatitis; concanavalin a; human; priority journal; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; phytohemagglutinins; t-lymphocytes, suppressor-effector; blood and hemopoietic system; dermatitis, atopic
Journal Title: Clinical & Experimental Allergy
Volume: 15
Issue: 1
ISSN: 0954-7894
Publisher: Wiley-Blackwell Publishing, Inc.  
Date Published: 1985-01-01
Start Page: 67
End Page: 72
Language: English
DOI: 10.1111/j.1365-2222.1985.tb02257.x
PUBMED: 3156692
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85004778820&doi=10.1111%2fj.1365-2222.1985.tb02257.x&partnerID=40&md5=be6ec96687164611ecd190e6c73341ba
Notes: Article -- Export Date: 26 October 2021 -- Source: Scopus
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