Innate immune activation and CD4+ T cell priming during respiratory fungal infection Journal Article


Authors: Rivera, A.; Ro, G.; Van Epps, H. L.; Simpson, T.; Leiner, I.; Sant'angelo, D. B.; Pamer, E. G.
Article Title: Innate immune activation and CD4+ T cell priming during respiratory fungal infection
Abstract: Aspergillus fumigatus is a mold that causes a spectrum of diseases, including lethal lung infections in immunocompromised humans and allergic asthma in atopic individuals. T helper 1 (Th1) CD4+ T cells protect against invasive A. fumigatus infections whereas Th2 CD4+ T cells exacerbate asthma upon inhalation of A. fumigatus spores. Herein, we demonstrate that A. fumigatus-specific T cells were rapidly primed in lymph nodes draining the lung and fully differentiated into interferon-γ (IFN-γ)-producing Th1 CD4+ T cells upon arrival in the airways. T-bet induction in A. fumigatus-specific CD4+ T cells was enhanced by MyD88-mediated signals in draining lymph nodes, but T cell proliferation, trafficking, and Th1 differentiation in the airways were Toll-like receptor (TLR) and MyD88 independent. Our studies demonstrate that CD4+ T cell differentiation during respiratory fungal infection occurs incrementally, with TLR-mediated signals in the lymph node enhancing the potential for IFN-γ production whereas MyD88-independent signals promote Th1 differentiation in the lung. © 2006 Elsevier Inc. All rights reserved.
Keywords: signal transduction; nonhuman; lymph nodes; cell proliferation; lymphocyte proliferation; animal cell; mouse; animals; mice; animal experiment; animal model; mice, mutant strains; antigen presentation; lymphocyte activation; microbio; gamma interferon; lymph node; cd4+ t lymphocyte; cell movement; adaptor proteins, signal transducing; cytokine production; innate immunity; asthma; th1 cell; disease exacerbation; mycosis; myeloid differentiation factor 88; toll like receptor; aspergillus fumigatus; aspergillosis; respiratory tract infection; cellimmuno; fungal strain; th1 cells; immunity, natural; interferon type ii; lung diseases, fungal
Journal Title: Immunity
Volume: 25
Issue: 4
ISSN: 1074-7613
Publisher: Cell Press  
Date Published: 2006-10-01
Start Page: 665
End Page: 675
Language: English
DOI: 10.1016/j.immuni.2006.08.016
PUBMED: 17027299
PROVIDER: scopus
DOI/URL:
Notes: --- - "Cited By (since 1996): 60" - "Export Date: 4 June 2012" - "CODEN: IUNIE" - "Source: Scopus"
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MSK Authors
  1. Eric Pamer
    277 Pamer
  2. Ingrid Leiner
    49 Leiner
  3. Grace S Ro
    2 Ro