Innate immune activation and CD4+ T cell priming during respiratory fungal infection Journal Article
| Authors: | Rivera, A.; Ro, G.; Van Epps, H. L.; Simpson, T.; Leiner, I.; Sant'angelo, D. B.; Pamer, E. G. |
| Article Title: | Innate immune activation and CD4+ T cell priming during respiratory fungal infection |
| Abstract: | Aspergillus fumigatus is a mold that causes a spectrum of diseases, including lethal lung infections in immunocompromised humans and allergic asthma in atopic individuals. T helper 1 (Th1) CD4+ T cells protect against invasive A. fumigatus infections whereas Th2 CD4+ T cells exacerbate asthma upon inhalation of A. fumigatus spores. Herein, we demonstrate that A. fumigatus-specific T cells were rapidly primed in lymph nodes draining the lung and fully differentiated into interferon-γ (IFN-γ)-producing Th1 CD4+ T cells upon arrival in the airways. T-bet induction in A. fumigatus-specific CD4+ T cells was enhanced by MyD88-mediated signals in draining lymph nodes, but T cell proliferation, trafficking, and Th1 differentiation in the airways were Toll-like receptor (TLR) and MyD88 independent. Our studies demonstrate that CD4+ T cell differentiation during respiratory fungal infection occurs incrementally, with TLR-mediated signals in the lymph node enhancing the potential for IFN-γ production whereas MyD88-independent signals promote Th1 differentiation in the lung. © 2006 Elsevier Inc. All rights reserved. |
| Keywords: | signal transduction; nonhuman; lymph nodes; cell proliferation; lymphocyte proliferation; animal cell; mouse; animals; mice; animal experiment; animal model; mice, mutant strains; antigen presentation; lymphocyte activation; microbio; gamma interferon; lymph node; cd4+ t lymphocyte; cell movement; adaptor proteins, signal transducing; cytokine production; innate immunity; asthma; th1 cell; disease exacerbation; mycosis; myeloid differentiation factor 88; toll like receptor; aspergillus fumigatus; aspergillosis; respiratory tract infection; cellimmuno; fungal strain; th1 cells; immunity, natural; interferon type ii; lung diseases, fungal |
| Journal Title: | Immunity |
| Volume: | 25 |
| Issue: | 4 |
| ISSN: | 1074-7613 |
| Publisher: | Cell Press |
| Date Published: | 2006-10-01 |
| Start Page: | 665 |
| End Page: | 675 |
| Language: | English |
| DOI: | 10.1016/j.immuni.2006.08.016 |
| PUBMED: | 17027299 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 60" - "Export Date: 4 June 2012" - "CODEN: IUNIE" - "Source: Scopus" |
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