Aberrant tissue localization of fungus-specific CD4(+) T cells in IL-10-deficient mice Journal Article
| Authors: | Rivera, A.; Collins, N.; Stephan, M. T.; Lipuma, L.; Leiner, I.; Pamer, E. G. |
| Article Title: | Aberrant tissue localization of fungus-specific CD4(+) T cells in IL-10-deficient mice |
| Abstract: | Aspergillus fumigatus, a common environmental fungus, can cause lethal invasive infections in immunocompromised hosts. In immunocompetent individuals, however, inhaled A. fumigatus spores prime CD4(+) T cells and activate immune responses that prevent invasive infection. Calibration of inflammatory responses to levels that prevent fungal invasion without inducing collateral tissue damage is essential for host survival, but the underlying regulatory mechanisms remain undefined. Although IL-10 is a validated regulatory cytokine that suppresses immune responses, and IL-10 deficiency or blockade generally enhances immune responses, we find that A. fumigatus-specific T cell frequencies are markedly reduced in airways of IL-10-deficient mice. T cell priming, proliferation, and survival were unaffected by IL-10 deficiency and did not account for decreased frequencies of A. fumigatus-specific T cells in the airways of IL-10-deficient mice. Instead, IL-10 deficiency results in redistribution of A. fumigatusspecific T cells from infected lungs to the gut, a process that is reversed by antibiotic-mediated depletion of intestinal microbes. Our studies demonstrate that disregulated immune responses in the gut can result in dramatic redistribution of pathogen-specific T cells within the host. Copyright © 2009 by The American Association of Immunologists, Inc. |
| Keywords: | controlled study; antibiotic agent; genetics; nonhuman; lymph nodes; cell proliferation; mouse; animal; mouse mutant; animals; mice; mice, knockout; cell survival; cells, cultured; apoptosis; interleukin 10; animal experiment; animal model; cell motion; pathology; mice, inbred c57bl; transgenic mouse; c57bl mouse; mice, transgenic; immunology; cell culture; tissue distribution; lymph node; cd4+ t lymphocyte; cd4-positive t-lymphocytes; epitope; lung; cell migration; cell movement; intestine flora; microbiology; epitopes, t-lymphocyte; intestine; mycosis; intestines; t lymphocyte activation; lymphocyte depletion; aspergillus fumigatus; aspergillosis; cell transfer; airway; interleukin-10 |
| Journal Title: | Journal of Immunology |
| Volume: | 183 |
| Issue: | 1 |
| ISSN: | 0022-1767 |
| Publisher: | The American Association of Immunologists, Inc |
| Date Published: | 2009-07-01 |
| Start Page: | 631 |
| End Page: | 641 |
| Language: | English |
| DOI: | 10.4049/jimmunol.0900396 |
| PUBMED: | 19542472 |
| PROVIDER: | scopus |
| PMCID: | PMC2753290 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 30 November 2010" - "CODEN: JOIMA" - "Source: Scopus" |
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