Is antibiotics prescription needed in infants with topical corticosteroids treatment for moderate-to-severe atopic dermatitis? Journal Article
| Authors: | Liu, Y.; Zhou, Q.; Dai, W.; Wang, S.; Liang, Y.; Li, Y.; Shen, C.; Li, D.; Li, Y.; Jiao, L.; Bian, Y.; Li, S.; Tang, Y. W.; Ma, L. |
| Article Title: | Is antibiotics prescription needed in infants with topical corticosteroids treatment for moderate-to-severe atopic dermatitis? |
| Abstract: | The cutaneous microbiota responses to skin health as well as atopic dermatitis. To reveal the microbiota effect in atopic dermatitis children under therapy with topical corticosteroids and antibiotics. 59 atopic dermatitis patients were randomized to two treatment groups (by corticosteroids or combination therapy) in Beijing Children's Hospital. The lesion microbial samples were collected for 16S rDNA sequencing and bioinformatics analysis. After treatment, 57 patients recovered significantly. Though topical antibiotics application blocked the restoration of commensal Streptococcus, no remarkable differences of cutaneous microbiota were identified between the two groups along the treatment. In subject 1081, who received the combination therapy, the Streptococcus and Pseudomonas as well as Chryseobacterium increased dramatically. On the contrary, the Staphylococcus aureus decreased sharply in subject 1107 with topical corticosteroids treatment Our preliminary study suggested the necessity to consider cutaneous microbiota profile when prescribing antibiotics. © 2020 Wiley Periodicals LLC. |
| Keywords: | controlled study; treatment outcome; antibiotic agent; antibiotic therapy; major clinical study; treatment duration; randomized controlled trial; bacterial strain; prescription; disease severity; infant; staphylococcus aureus; corticosteroid; bioinformatics; convalescence; pseudomonic acid; pediatric hospital; china; data collection method; antibiotics; commensal; pseudomonas; dna 16s; corticosteroid therapy; streptococcus; mometasone furoate; atopic dermatitis; dna sequencing; human; male; female; article; skin flora; cutaneous microbiota; chryseobacterium; severity scoring of atopic dermatitis |
| Journal Title: | Dermatologic Therapy |
| Volume: | 33 |
| Issue: | 6 |
| ISSN: | 1396-0296 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2020-11-01 |
| Start Page: | e14215 |
| Language: | English |
| DOI: | 10.1111/dth.14215 |
| PUBMED: | 32827193 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 February 2021 -- Source: Scopus |
