Comparison of murine lymphokine-activated killer cells, natural killer cells, and cytotoxic T lymphocytes Journal Article
| Author: | Merluzzi, V. J. |
| Article Title: | Comparison of murine lymphokine-activated killer cells, natural killer cells, and cytotoxic T lymphocytes |
| Abstract: | Precursors and effectors of murine lymphokine-activated killer cells, natural killer cells, and cytotoxic T lymphocytes are compared. Natural killer cells are resistant to γ-irradiation (1000 R) whereas precursors of lymphokine-activated killer cells and cytotoxic T lymphocytes are sensitive. Lower doses of γ-irradiation (500 R) remove precursors for cytotoxic T lymphocytes but not lymphokine-activated killer cells. In addition, lymphokine-activated killer cells are regenerated before classical CTL after sublethal doses of γ-irradiation. Natural killer cells are resistant to anti-Thy 1 and C' and anti-thymocyte serum, but sensitive to anti-asialo GM1 and complement. Precursors of cytotoxic T lymphocytes are sensitive to anti-Thy 1 and complement and anti-thymocyte serum, but are resistant to anti-asialo GM1 and complement. Precursors of lymphokine-activated killer cells are partially sensitive to anti-Thy 1 and complement and anti-thymocyte serum, but are resistant to anti-asialo GM1 and complement. Effector cells of cytotoxic T lymphocytes are sensitive to anti-Thy 1 and complement and resistant to anti-asialo GM1 and complement. Lymphokine-activated killer cell effectors are sensitive to anti-asialo GM1 and complement at 24 hr after activation. These effectors are more closely aligned with classical natural killer effectors. Lymphokine-activated killer effectors, 7 days after activation, are resistant to anti-asialo GM1 and complement and sensitive to anti-Thy 1 and complement. Relationships and differences among these cytotoxic subsets are discussed. © 1985. |
| Keywords: | nonhuman; comparative study; mouse; animal; mice; spleen; animal experiment; cell differentiation; time factors; mice, inbred strains; lymphocyte activation; cytotoxic t lymphocyte; t-lymphocytes, cytotoxic; natural killer cell; killer cells, natural; immunity, cellular; glycosphingolipids; gamma radiation; gamma rays; antilymphocyte serum; killer cell; male; priority journal; killer cells; support, u.s. gov't, p.h.s.; lymphokine |
| Journal Title: | Cellular Immunology |
| Volume: | 95 |
| Issue: | 1 |
| ISSN: | 0008-8749 |
| Publisher: | Elsevier Inc. |
| Date Published: | 1985-10-01 |
| Start Page: | 95 |
| End Page: | 104 |
| Language: | English |
| DOI: | 10.1016/0008-8749(85)90298-9 |
| PUBMED: | 3875426 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 26 October 2021 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work