Similarities and distinctions between murine natural killer cells and lymphokine-activated killer cells Journal Article
| Authors: | Merluzzi, V. J.; Smith, M. D.; Last-Barney, K. |
| Article Title: | Similarities and distinctions between murine natural killer cells and lymphokine-activated killer cells |
| Abstract: | Pretreatment of mice with rabbit anti-asialo GM1 removes both natural killer (NK) effector cells and NK cells responsive to interleukin 2 (IL-2). Spleen cells from these mice do possess normal lymphokine-activated killer (LAK) activity. Young mice (<3 weeks of age) do not have NK activity and do not possess IL-2-inducible NK effector cells. Similarly to anti-asialo GM1-treated mice, LAK cells can be generated from these mice. While these experiments indicate clear distinctions between a certain level of NK and LAK precursors, the distinctions are not as clear when analyzing mice congenitally deficient in NK cells. Beige mice which lack NK effector cells and IL-2-inducible NK cells also lack the ability to generate LAK cells. The relationships and differences between NK- and LAK-cell precursors and effectors are discussed. © 1986. |
| Keywords: | drug efficacy; nonhuman; comparative study; mouse; animal; mice; interleukin 2; spleen; in vitro study; mice, inbred c57bl; lymphocyte activation; natural killer cell; killer cells, natural; interleukin-2; spleen cell; glycosphingolipids; mice, inbred dba; antilymphocyte serum; killer cell; male; priority journal; lymphokines; support, u.s. gov't, p.h.s. |
| Journal Title: | Cellular Immunology |
| Volume: | 100 |
| Issue: | 2 |
| ISSN: | 0008-8749 |
| Publisher: | Elsevier Inc. |
| Date Published: | 1986-07-01 |
| Start Page: | 563 |
| End Page: | 569 |
| Language: | English |
| DOI: | 10.1016/0008-8749(86)90054-7 |
| PUBMED: | 3489533 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 18 August 2021 -- Source: Scopus |
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