Comparison of gas chromatographic/mass spectrometric and microbiological assays for 5‐fluorouracil in plasma Journal Article
| Authors: | Min, B. H.; Garland, W. A.; Lewinson, T. M.; Mehta, B. M. |
| Article Title: | Comparison of gas chromatographic/mass spectrometric and microbiological assays for 5‐fluorouracil in plasma |
| Abstract: | The concentrations of 5‐fluorouracil in 99 plasma samples were determined by both microbiological and gas chromatographic/mass spectrometric assays. The values determined by the two methods were similar (correlation coefficient = 0.90). A regression of the natural logarithms of the concentrations (0.01–94 μg ml−1) determined by the two methods gave a line whose slope and intercept were not statistically different (p>0.05) from 1 and 0 respectively. Thus, the microbiological assay has specificity over a sufficient concentration range to serve as a practical routine laboratory method for the determination of 5‐fluorouracil. Copyright © 1985 John Wiley & Sons, Ltd. |
| Keywords: | human cell; fluorouracil; comparative study; methodology; mass spectrometry; in vitro study; drug blood level; biological assay; mass fragmentography; drug determination; plasma; gas chromatography; streptococcus; human; preliminary communication; streptococcus faecalis; blood and hemopoietic system; drug analysis |
| Journal Title: | Biological Mass Spectrometry |
| Volume: | 12 |
| Issue: | 5 |
| ISSN: | 1052-9306 |
| Publisher: | John Wiley & Sons |
| Date Published: | 1985-05-01 |
| Start Page: | 238 |
| End Page: | 240 |
| Language: | English |
| DOI: | 10.1002/bms.1200120510 |
| PUBMED: | 3161554 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 26 October 2021 -- Source: Scopus |
