High-performance liquid chromatographic method for the simultaneous measurement of floxuridine and fluorouracil in human body fluids Journal Article
| Authors: | Smith-Rogers, J. A.; Tong, W. P.; Duafala, M. E.; Markman, M.; Bertino, J. R. |
| Article Title: | High-performance liquid chromatographic method for the simultaneous measurement of floxuridine and fluorouracil in human body fluids |
| Abstract: | A method for the simultaneous measurement of floxuridine (5-fluorodeoxyuridine) and fluorouracil in human plasma and peritoneal fluid has been developed. This method utilizes high-performance liquid chromatographic analysis with a Zorbax RX column (25 cm × 4.6 mm I.D.) plus a guard cartridge of the same material. The sensitivity limits for this assay are 0.25 μmol/l in a 20-μl sample. The detection limit at a signal-to-noise ratio of 3 is 2.5 nmol/l. This procedure has been used to quantitatively measure concentration versus time profiles of floxuridine and fluorouracil in plasma and peritoneal fluid of human patients after receiving intraperitoneal administration of floxuridine. © 1991. |
| Keywords: | fluorouracil; body fluids; high performance liquid chromatography; chromatography, high pressure liquid; floxuridine; ascitic fluid; body fluid; middle age; peritoneal fluid; intraperitoneal drug administration; drug mixture; human; male; female; priority journal; article; support, non-u.s. gov't; congenital disorder |
| Journal Title: | Journal of Chromatography. Biomedical Applications |
| Volume: | 566 |
| Issue: | 1 |
| ISSN: | 0378-4347 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 1991-05-03 |
| Start Page: | 147 |
| End Page: | 154 |
| Language: | English |
| DOI: | 10.1016/0378-4347(91)80119-w |
| PUBMED: | 1832171 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 27 September 2019 -- Source: Scopus |
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